{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:16:38Z","timestamp":1775715398131,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess the sleep quality of patients with primary Sj\u00f6gren\u2019s syndrome (pSS) and the associated factors. Moreover, we conducted a preliminary exploration of the clinical significance of serum brain-derived neurotrophic factor (BDNF) in pSS patients with sleep disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A self-report survey was administered to 111 pSS patients and 40 healthy individuals using the Pittsburgh Sleep Quality Index for sleep quality. Clinical data, and mental conditions were collected using on-site questionnaires and various scales. A total of 40 healthy controls from the health examination centre of the same hospital, who were age- and sex-matched. Detection of serum BDNF levels by enzyme-linked immunosorbent assay method. Use GraphPad Prism to analyze data and create graphs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with pSS had higher scores on the Pittsburgh Sleep Quality Index than the healthy individuals. Abnormal sweating, high Patient Health Questionnaire-9 and EULAR Sj\u00f6gren Syndrome Patient Reported Index scores were independent risk factors for sleep disorders. pSS patients had lower serum BDNF than the healthy individuals. The area under the curve of predicting sleep disorder in pSS patients using detection of serum BDNF level was 0.8470, and the sensitivity and specificity were 0.951 and 0.727, which were superior to Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with the healthy individuals, pSS patients had a higher prevalence of sleep disorders and lower serum BNDF. Serum BDNF level demonstrated greater predictive advantage for sleep disorder in pSS patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae071","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T18:37:49Z","timestamp":1724783869000},"page":"332-338","source":"Crossref","is-referenced-by-count":3,"title":["A study on factors related to sleep disorders and serum BDNF expression levels in patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"35","author":[{"given":"Yaxin","family":"Han","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The People\u2019s Hospital of WenJiang , Chengdu,","place":["China"]},{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China , Chengdu,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xixi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China , Chengdu,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Tang","sequence":"additional","affiliation":[{"name":"Nephropathy and Rheumatic Immune Clinic, Bishan Hospital of Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Chengdu Second People\u2019s Hospital , Chengdu,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College , Chengdu, Sichuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College , Chengdu, Sichuan,","place":["China"]},{"name":"Zunyi Medical University , Zunyi, Guizhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China , Chengdu,","place":["China"]},{"name":"Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province , Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China, Chengdu,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China , Chengdu,","place":["China"]},{"name":"Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province , Sichuan Provincial People\u2019s Hospital, school of medicine, University of Electronic Science and Technology of China, Chengdu,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"2025030423304992900_R1","article-title":"Primary Sjogren\u2019s syndrome","volume":"379","author":"Mariette","year":"2018","journal-title":"New Engl J Med"},{"key":"2025030423304992900_R2","first-page":"659","article-title":"Prevalence of primary 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