{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:51:36Z","timestamp":1783525896586,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess the unmet medical needs of young adult patients with juvenile idiopathic arthritis (JIA) by evaluating real-world treatment data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed data on JIA in the age group of 20\u201329\u2009years from the National Database of Designated Incurable Diseases of Japan, which records severe cases or those requiring high-cost medical care registered between April 2018 and March 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 322 patients with JIA transitioning to adulthood were included. A high frequency of methotrexate use was observed among all JIA subtypes. The frequency of methotrexate use at registration was significantly higher in patients with rheumatoid factor\u2013positive polyarthritis and those with oligoarthritis or polyarthritis than in those with systemic arthritis. The historical use percentage of any biological disease\u2013modifying antirheumatic drug was \u226585% for all JIA subtypes. The proportion of patients with \u22652 biological disease\u2013modifying antirheumatic drug prescriptions was significantly higher in patients with rheumatoid factor\u2013positive polyarthritis than in those with systemic arthritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High-cost drugs were necessary for many patients with JIA transitioning to young adulthood and registered in the database. Further studies on the medical interventions and support for these patients are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae076","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:32:14Z","timestamp":1724369534000},"page":"359-365","source":"Crossref","is-referenced-by-count":3,"title":["Nationwide epidemiological survey of juvenile idiopathic arthritis during transition to young adulthood in Japan using the National Database of Designated Incurable Diseases of Japan"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5904-687X","authenticated-orcid":false,"given":"Yuzaburo","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of General Medical Science, Graduate School of Medicine, Chiba University , Chiba,","place":["Japan"]},{"name":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Meiji Pharmaceutical University , Tokyo,","place":["Japan"]},{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Showa University Research Administration Center, Showa University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Mitsunaga","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergology, St. Marianna University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Center for Preventive Medical Sciences, Chiba University , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Miyamae","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"2025030423303648200_R1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2025030423303648200_R2","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1950-7","article-title":"Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era","volume":"21","author":"Giancane","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2025030423303648200_R3","first-page":"1086","article-title":"Patients with juvenile idiopathic arthritis become adults: the role of transitional care","volume":"36","author":"Conti","year":"2018","journal-title":"Clin Exp 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College of Rheumatology Guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for oligoarthritis, temporomandibular joint arthritis, and systemic juvenile idiopathic arthritis","volume":"74","author":"Onel","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2025030423303648200_R14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/14397595.2018.1514724","article-title":"Clinical practice guidance for juvenile idiopathic arthritis (JIA) 2018","volume":"29","author":"Okamoto","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2025030423303648200_R15","doi-asserted-by":"crossref","DOI":"10.1186\/s12969-022-00769-5","article-title":"Discontinuation of biologic DMARDs in non-systemic JIA patients: a scoping review of relapse rates and associated factors","volume":"20","author":"Gieling","year":"2022","journal-title":"Pediatr Rheumatol Online 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