{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:33:04Z","timestamp":1775147584640,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the prevalence and outcomes among regimens of glucocorticoid tapering for microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in real-world practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively examined the Japan Collaborative Registry of Antineutrophil Cytoplasmic Antibodies-associated Vasculitis (J-CANVAS) registry, and evaluated the prevalence of glucocorticoid tapering regimens in the PEXIVAS trial. In patients with newly diagnosed MPA and GPA, we compared outcomes among standard and reduced pace regimens. Relapse-free survival rates were compared after propensity score matching.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 364 eligible patients, 113 (31.0%) received standard tapering and 251 slower tapering. After matching, 87 pairs no significant difference was observed in relapse-free survival (P\u2009=\u2009.506). Regarding the reduced regimen, there were so few patients (14\/364, 3.8%) that statistical analysis was not performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The glucocorticoid tapering for MPA and GPA in Japanese real-world practice was found to be generally slower than the standard regimen revealing a huge evidence-practice gap. Additionally, slower tapering did not improve relapse-free survival and might cause unnecessary glucocorticoid exposure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae112","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T06:15:46Z","timestamp":1735020946000},"page":"496-504","source":"Crossref","is-referenced-by-count":1,"title":["Glucocorticoid tapering pace in microscopic polyangiitis and granulomatosis with polyangiitis in Japanese real-world practice: A propensity score-matched retrospective cohort study from the J-CANVAS registry"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-7311","authenticated-orcid":false,"given":"Ryo","family":"Nishioka","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology, Graduate School of Medical Science, Kanazawa University , Kanazawa,","place":["Japan"]},{"name":"Department of General Medicine, Kanazawa University Hospital , Kanazawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Omura","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Yamanashi Hospital , Yamanashi,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Center for Rheumatic Disease, Japanese Red Cross Society Kyoto Daiichi Hospital , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoho","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Chubu Rosai Hospital , Nagoya,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Immuno-Rheumatology Center, St. Luke\u2019s International Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kukida","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Japanese Red Cross Society Kyoto Daini Hospital , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kyoto Katsura Hospital , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy, Tosei General Hospital , Seto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology, Kagoshima University Hospital , Kagoshima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of General internal medicine, Tottori Prefectural Central Hospital , Tottori-shi,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital , Hiroshima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University , Nishinomiya,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki,","place":["Japan"]},{"name":"Department of Rheumatology, Shimane University, Faculty of Medicine , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine, Hokkaido University , Sapporo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yanai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Kyosai Hospital , Kyoto,","place":["Japan"]},{"name":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine , Matsumoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University , Tottori-shi,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Takata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nephrology, Tottori University , Tottori-shi,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Shimane University Hospital , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Shimane University, Faculty of Medicine , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayuko","family":"Takatani","sequence":"additional","affiliation":[{"name":"Rheumatic Disease Center, Sasebo Chuo Hospital , Sasebo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshia","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Ito-Ihara","sequence":"additional","affiliation":[{"name":"The Clinical and Translational Research Center, University Hospital, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Practical Pharmacy, Tokyo University of Pharmacy and Life Sciences , Hachioji,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Yajima","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University , Kyoto,","place":["Japan"]},{"name":"Center for Innovative Research for Communities and Clinical Excellence, Fukushima Medical University , Fukushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kida","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kawahito","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Graduate School of Medical Science, Kanazawa University , Kanazawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2025050812114474600_R1","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-020-0204-y","article-title":"ANCA-associated vasculitis","volume":"6","author":"Kitching","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2025050812114474600_R2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2215\/CJN.02500317","article-title":"ANCA glomerulonephritis and vasculitis","volume":"12","author":"Jennette","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025050812114474600_R3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.7326\/0003-4819-150-10-200905190-00004","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial","volume":"150","author":"de 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