{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:01:14Z","timestamp":1778076074971,"version":"3.51.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To identify factors associated with probable sarcopenia in patients with rheumatoid arthritis (RA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Probable sarcopenia was diagnosed using the SARC-F questionnaire. Patients with difficult-to-treat RA (D2T-RA) were defined as those with a history of using \u22652 biological\/targeted synthetic (b\/ts) disease-modifying antirheumatic drugs (b\/tsDMARDs) who had moderate or high disease activity. Among 486 patients, 101 were classified into the probable sarcopenia group (SARC-F \u22654), and 385 were classified into the non-probable sarcopenia group (SARC-F &amp;lt;4). Factors associated with probable sarcopenia were examined using multiple logistic regression analysis. Additionally, patients were divided into the D2T-RA (n\u2009=\u200938) and non-D2T-RA (n\u2009=\u2009448) groups, and the proportion of probable sarcopenia and RA treatment status were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Factors associated with probable sarcopenia included age [adjusted odds ratio (OR): 1.03], body mass index (OR: 1.16), D2T-RA (OR: 3.39), and Health Assessment Questionnaire-Disability Index (OR: 1.38), and diabetes mellitus (OR: 2.77). The proportion of probable sarcopenia was significantly higher (60.5% vs. 17.4%), and the rate of methotrexate use was significantly lower (34.2% vs. 64.1%), in the D2T-RA group than in the non-D2T-RA group. Moreover, in the D2T-RA group, most patients used two or three b\/tsDMARDs (two: 68.4%, three: 21.1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>D2T-RA was associated with probable sarcopenia. Tight control by treatment enhancement may help overcome sarcopenia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae116","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T08:39:58Z","timestamp":1735547998000},"page":"410-416","source":"Crossref","is-referenced-by-count":2,"title":["The association between difficult-to-treat rheumatoid arthritis and probable sarcopenia"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-6928","authenticated-orcid":false,"given":"Yoshifumi","family":"Ohashi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Aichi Medical University, Graduate School of Medicine , Nagakute, Aichi 4801103,","place":["Japan"]},{"name":"Department of Orthopedic Surgery, Yokkaichi Municipal Hospital, Yokkaichi , Mie 5108567,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mochihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Japan Community Health Care Organization, Kani Tono Hospital , Kani, Gifu 5090206,","place":["Japan"]},{"name":"Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Aichi 4668560,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumori","family":"Sobue","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Japan Red Cross Aichi Medical Center, Nagoya Daiichi Hospital , Nagoya, Aichi 4538511,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Terabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Aichi 4668560,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Aichi 4668560,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobunori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Aichi Medical University, Graduate School of Medicine , Nagakute, Aichi 4801103,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Aichi 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