{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:09:46Z","timestamp":1794344986916,"version":"4.9.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cytomegalovirus (CMV) reactivation during immunosuppressive therapy poses a risk of severe infections. This study aimed to investigate the risk factors of CMV reactivation in patients with microscopic polyangiitis and granulomatosis with polyangiitis using a nationwide cohort in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study used data from the Japan Collaborative Registry of antineutrophil cytoplasmic antibody-associated vasculitis. The outcome was as CMV reactivation up to 48\u2009weeks after treatment initiation. We explored the risk factors for CMV reactivation by comparing the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 454 patients, CMV reactivation occurred in 89 (19.6%). The univariate analysis showed that patients with CMV reactivation were older (P\u2009&amp;lt;\u2009.001), had higher Birmingham Vasculitis Activity Scores (BVAS) (P\u2009=\u2009.004) and BVAS renal scores (P\u2009&amp;lt;\u2009.001), and had received glucocorticoid pulse (P\u2009=\u2009.004). The logistic regression analysis showed that hypoalbuminemia (odds ratio: 0.55, 95% confidence interval: 0.31\u20130.98), and low serum IgG (OR: 0.94, 95% CI: 0.89\u20131.00) were risk factors for CMV reactivation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hypoalbuminemia and low serum IgG levels were risk factors for CMV reactivation. It is necessary to accurately identify high-risk patients and closely monitor their condition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roaf008","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T23:19:29Z","timestamp":1738279169000},"page":"691-696","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for cytomegalovirus reactivation during the treatment of ANCA-associated vasculitis: A retrospective cohort study of the J-CANVAS study"],"prefix":"10.1093","volume":"35","author":[{"given":"Kazutaka","family":"Kawamori","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6187-1550","authenticated-orcid":false,"given":"Nao","family":"Oguro","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunika","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-8352","authenticated-orcid":false,"given":"Takashi","family":"Kida","sequence":"additional","affiliation":[{"name":"Graduate Inflammation and Immunology, School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-2044","authenticated-orcid":false,"given":"Satoshi","family":"Omura","sequence":"additional","affiliation":[{"name":"Graduate Inflammation and Immunology, School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-9799","authenticated-orcid":false,"given":"Daiki","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Yamanashi Hospital , Yamanashi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-2868","authenticated-orcid":false,"given":"Yoshiyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Center for Rheumatic Disease, Japanese Red Cross Society Kyoto Daiichi Hospital , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-3537","authenticated-orcid":false,"given":"Naoho","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Chubu Rosai Hospital , Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-6273","authenticated-orcid":false,"given":"Atsushi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Immuno-Rheumatology Center, St. Luke\u2019s International Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-4533","authenticated-orcid":false,"given":"Yuji","family":"Kukida","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Japanese Red Cross Society Kyoto Daini Hospital , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kyoto Katsura Hospital , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy, Tosei General Hospital , Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Graduate Inflammation and Immunology, School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]},{"name":"Department of Hematology and Rheumatology, Kagoshima University Hospital , Kagoshima,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of General internal medicine, Tottori Red Cross Hospital , Tottori,","place":["Jaoan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-9943","authenticated-orcid":false,"given":"Shintaro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital , Hiroshima,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-4172","authenticated-orcid":false,"given":"Kiyoshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine , 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Shinshu University School of Medicine , Nagano,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-7311","authenticated-orcid":false,"given":"Ryo","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Graduate School of Medical Science, Kanazawa University , Ishikawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University , Tottori,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-6015","authenticated-orcid":false,"given":"Tomoaki","family":"Takata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nephrology, Tottori University , Tottori,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-6566","authenticated-orcid":false,"given":"Takafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology, Teikyo University Chiba Medical Center , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Shimane University Faculty of Medicine , Shimane,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Takatani","sequence":"additional","affiliation":[{"name":"Rheumatic Disease Center, Sasebo Chuo Hospital , 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