{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:54:05Z","timestamp":1757609645207,"version":"3.44.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the oral health-related quality of life (OHRQoL) in Sj\u00f6gren\u2019s disease (SjD) patients with unstimulated whole salivary flow (UWSF) \u22650.1\u2009ml\/min for whom no preferred therapeutic approaches are provided in the European League Against Rheumatism recommendations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-four SjD patients and 23 controls were enrolled in this study. The UWSF was measured using the spitting method. OHRQoL was quantitatively evaluated using the short-form Oral Health Impact Profile (OHIP-14).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In SjD patients, 26 (76.5%) had a UWSF &amp;lt;0.1\u2009ml\/min, and 8 (23.5%) had \u22650.1\u2009ml\/min. The OHIP-14 scores were significantly higher in both the \u22650.1 and &amp;lt;0.1\u2009ml\/min groups than in the non-SjD group. Among the OHIP-14 questions, the \u22650.1\u2009ml\/min group scored significantly higher than the non-SjD group for \u2018uncomfortable to eat foods\u2019, \u2018self-conscious\u2019, \u2018diet unsatisfactory\u2019, \u2018difficult to relax\u2019, \u2018felt life less satisfying\u2019, and \u2018unable to function\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Even with UWSF \u22650.1\u2009ml\/min, SjD patients had lower OHRQoL. The normal range of salivary flow rates is wide, exhibiting high interindividual variability. Even if the salivary flow rate is preserved in a single measurement, the possibility of having oral dryness due to a decrease in the salivary flow rate from the normal value for that patient should be considered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roaf023","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T05:47:26Z","timestamp":1742017646000},"page":"866-871","source":"Crossref","is-referenced-by-count":0,"title":["Oral health-related quality of life in Sj\u00f6gren\u2019s disease patients with unstimulated whole salivary flows \u22650.1 ml\/min for whom no therapeutic approaches are provided in the EULAR recommendations"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-1535","authenticated-orcid":false,"given":"Naoto","family":"Azuma","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , 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Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-2608","authenticated-orcid":false,"given":"Teppei","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]},{"name":"Department of Clinical Diagnostic and Laboratory Medicine, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]},{"name":"Department of Rheumatology, Nishinomiya Watanabe Hospital , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine , Hyogo,","place":["Japan"]},{"name":"Department of Rheumatology, Sumitomo Hospital , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, 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