{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:53:34Z","timestamp":1757609614082,"version":"3.44.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate differences in information obtained from plain computed tomography (CT) and diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) during malignancy screening in patients with rheumatoid arthritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 524 patients with RA who underwent plain CT from the chest to the pelvis and DWIBS. CT and DWIBS were performed within 3 months of each other. Rheumatologists, radiologists, and pulmonologists interpreted the plain CT and DWIBS images.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of malignancy was 3.1%. Prostate, lung, breast, uterine, ovarian, and fallopian tube cancers were detected in 7, 4, 2, 1, 1, and 1 patient, respectively. The sensitivities of CT and DWIBS were 75.0% and 93.8%, respectively (P\u2009=\u2009.333). The specificities of CT and DWIBS were 76.0% and 85.8%, respectively (P\u2009&amp;lt;\u2009.001). The prevalence rates of interstitial lung disease, colonic diverticula, and kidney stones on CT were 17.6%, 27.1%, and 19.1%, respectively. The prevalence of lymphadenopathy in patients who underwent DWIBS was 3.6%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study suggests that DWIBS is superior to or equivalent to CT for malignancy screening. Our findings have important implications for imaging-based screening and can help address cancer-related issues in rheumatoid arthritis treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roaf030","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T07:13:51Z","timestamp":1742714031000},"page":"837-842","source":"Crossref","is-referenced-by-count":0,"title":["Imaging assessment of malignancy screening using computed tomography and diffusion-weighted whole-body imaging with background body signal suppression in rheumatoid arthritis"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-8671","authenticated-orcid":false,"given":"Takeshi","family":"Mochizuki","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Ikari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Hiroshima","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"2025090306272909100_R1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/mr\/roab126","article-title":"Trend in prescription and treatment retention of molecular-targeted drugs in 121,131 Japanese patients with rheumatoid arthritis: a population-based real-world study","volume":"32","author":"Takabayashi","year":"2022","journal-title":"Mod Rheumatol"},{"key":"2025090306272909100_R2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/mr\/roab122","article-title":"Seasonal exacerbation of rheumatoid arthritis detected by big claims data analysis: a retrospective 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