{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:14:53Z","timestamp":1775664893178,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate real-world data on the demographics, prescribing practices, and healthcare costs of juvenile idiopathic arthritis (JIA) with polyarthritis or oligoarthritis compared to rheumatoid arthritis (RA) patients in adolescents and young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the Japan Medical Data Center claims database for fiscal year (FY) 2016 to FY 2020 were analysed. JIA and RA were defined as having at least 2\u2009months of disease-modifying antirheumatic drug (DMARD) prescriptions and corresponding International Classification of Diseases, 10th Revision codes for each FY. Therapeutic drug prescriptions and direct medical costs were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 5,064,539 eligible individuals aged 18\u201329\u2009years, 202 were identified with JIA and 2758 with RA. The prescription rate of biologic and targeted synthetic DMARDs (tsDMARDs) for RA remained stable at \u223c40% between FY 2016 and FY 2020. However, from FY 2018 onward, the rate was significantly higher for JIA, reaching \u223c60% (P\u2009&amp;lt;\u2009.05). In FY 2020, biosimilar prescriptions accounted for 15% in RA but only 3% in JIA. Direct medical costs for JIA were 1.6 times higher than those for RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with JIA were more frequently prescribed tsDMARDs and less likely to receive biosimilars, contributing to higher healthcare costs compared to RA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf035","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T15:24:59Z","timestamp":1744039499000},"page":"935-943","source":"Crossref","is-referenced-by-count":2,"title":["Comparative clinical practice of juvenile idiopathic arthritis and rheumatoid arthritis in adolescents and young adults: A retrospective cohort study using Japanese health insurance claims data (2016\u201320)"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-1496","authenticated-orcid":false,"given":"Takako","family":"Miyamae","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women\u2019s Medical University Hospital , Tokyo,","place":["Japan"]},{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Department of Public Health and Epidemiology, Meiji Pharmaceutical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzaburo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of General Medical Science, Graduate School of Medicine, Chiba University , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Showa University Research Administration Center, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nishinomiya Municipal Central Hospital , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine , Matsumoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Mitsunaga","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Lifelong Immunotherapy, Institute of Science , Tokyo,","place":["Japan"]},{"name":"Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine , Kawasaki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Narazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Nishikomori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Kurume University School of Medicine , Fukuoka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Development Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe City Medical Center General Hospital , Hyogo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Japanese Red Cross Otsu Hospital , Otsu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Nerima Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Yokogawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Yoshifuji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, 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