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The effects of low-pressure hypoxia brought on by high-altitude surroundings and intestinal hypoxia have received comparatively less attention, even though hypoxia is a distinct state in the synovium of RA. In an effort to offer fresh approaches and ideas for treating RA, reducing pain, and enhancing quality of life, this review updates the mechanism of synovial hypoxia on RA in recent years. It also advances the theory that intestinal hypoxia and low-pressure hypoxia in the external environment aggravate arthritis.<\/jats:p>","DOI":"10.1093\/mr\/roaf046","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T01:04:17Z","timestamp":1748826257000},"page":"787-800","source":"Crossref","is-referenced-by-count":2,"title":["The effect of hypoxia on rheumatoid arthritis"],"prefix":"10.1093","volume":"35","author":[{"given":"Anting","family":"Liu","sequence":"first","affiliation":[{"name":"Graduate School of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenlu","family":"Huo","sequence":"additional","affiliation":[{"name":"Graduate School of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Qian","sequence":"additional","affiliation":[{"name":"Graduate School of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Tuina, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"2025090306274141500_ref1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/ajcn\/nqaa019","article-title":"Anti-inflammatory diet in rheumatoid arthritis (ADIRA)\u2014a randomized, controlled crossover trial indicating effects on disease activity","volume":"111","author":"Vadell","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"2025090306274141500_ref2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1001\/jama.2022.0786","article-title":"What is rheumatoid arthritis?","volume":"327","author":"Smith","year":"2022","journal-title":"JAMA"},{"key":"2025090306274141500_ref3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/art.42442","article-title":"Disease activity and health-related quality of life among patients with rheumatoid arthritis with different alcohol consumption habits","volume":"75","author":"Alfredsson","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2025090306274141500_ref4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12890-023-02594-2","article-title":"Secular trend of mortality and incidence of rheumatoid arthritis in global, 1990\u20132019: an age period cohort analysis and joinpoint analysis","volume":"23","author":"Yu","year":"2023","journal-title":"BMC Pulm Med"},{"key":"2025090306274141500_ref5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/annrheumdis-2019-216694","article-title":"Is the epidemiology of rheumatoid arthritis changing? 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