{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:01:18Z","timestamp":1776909678474,"version":"3.51.2"},"reference-count":152,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Articular involvement is one of the most common findings of Behcet\u2019s disease. This study aimed to systematically evaluate the trends in the prevalence of arthritis and arthralgia in patients with Behcet\u2019s disease, as well as their potential associations with extra-articular manifestations of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational studies that reported the prevalence of arthritis or arthralgia were included. Pooled prevalence with corresponding 95% confidence intervals (CIs) were calculated. Univariate metaregression was performed to evaluate the potential associations of articular manifestations with extra-articular manifestations of Behcet\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 120 articles were included. The pooled prevalence of arthritis and arthralgia were 0.34 (95% CI: 0.30\u20130.39) and 0.37 (95% CI: 0.30\u20130.45). The peripheral joints were mostly affected in the form of oligoarthritis. There were significant positive associations between the prevalence of arthralgia and the proportion of females and skin lesions, and between the prevalence of arthritis and skin lesions and erythema nodosum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlighted a decreasing trend of arthritis over the years and the predominance of peripheral involvement and oligoarthritis, particularly in the knees. Additionally, it showed that there are significant associations but not necessarily causal relationships between the prevalence of arthritis and arthralgia and of skin lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf049","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T11:48:32Z","timestamp":1752148112000},"page":"1015-1029","source":"Crossref","is-referenced-by-count":1,"title":["The trends in the prevalence of arthritis and arthralgia and their associations with extra-articular manifestations in patients with Behcet\u2019s disease: A systematic review and meta-analysis"],"prefix":"10.1093","volume":"35","author":[{"given":"Aida","family":"Mohamadi","sequence":"first","affiliation":[{"name":"Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Karimi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr","family":"Nayebirad","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannaneh","family":"Yousefi-Koma","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Tamartash","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Atef-Yekta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Rezakhani","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences , Tehran 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