{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:32:25Z","timestamp":1791995545781,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of romosozumab in older Japanese patients with osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bone mineral density (BMD) was measured at 0, 4, 6, and 12\u00a0months after romosozumab treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 125 patients with osteoporosis (mean age: 77.6\u2009\u00b1\u20097.5\u00a0years), 115 completed BMD measurements at the lumbar spine, total hip, and femoral neck. The BMD at the lumbar spine (11.5%, P\u2009&amp;lt;\u2009.01), total hip (3.0%, P\u2009&amp;lt;\u2009.01), and femoral neck (3.7%, P\u2009&amp;lt;\u2009.01) increased 12\u00a0months after treatment. There were no differences in the improvement ratio of BMD after 12\u00a0months of treatment at the lumbar spine, total hip, and femoral neck among 76 patients aged \u226575\u00a0years and 39 aged &amp;lt;75\u00a0years (11.0% vs. 12.5%: P\u2009=\u2009.48, 3.0% vs. 3.0%: P\u2009=\u2009.83, 3.6% vs. 4.1%: P\u2009=\u2009.92), 48 with prior treatment of osteoporosis and 67 without prior treatment of osteoporosis (10.8% vs. 12.1%: P\u2009=\u2009.56, 2.1% vs. 3.7%: P\u2009=\u2009.25, 2.8% vs. 4.5%: P\u2009=\u2009.61), and 55 patients with a history of fragility fracture and 60 without a history of fragility fracture (11.8% vs. 11.3%: P\u2009=\u2009.88, 2.4% vs. 3.5%: P\u2009=\u2009.51, 2.0% vs. 5.3: P\u2009=\u2009.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Romosozumab improved BMD at the lumbar spine, total hip, and femoral neck in older adults with osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf054","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:54:04Z","timestamp":1749196444000},"page":"1057-1064","source":"Crossref","is-referenced-by-count":1,"title":["Romosozumab increases bone mineral density in Japanese older adults with osteoporosis"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-0721","authenticated-orcid":false,"given":"Shohei","family":"Anno","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Yodogawa Christian Hospital , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Okano","sequence":"additional","affiliation":[{"name":"Center for Senile Degenerative Disorders (CSDD), Osaka Metropolitan University, Graduate School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sugioka","sequence":"additional","affiliation":[{"name":"Center for Senile Degenerative Disorders (CSDD), Osaka Metropolitan University, Graduate School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Wakitani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koryokai Hospital , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koryokai Hospital , Osaka ,","place":["Japan"]},{"name":"Department of Orthopeadic Surgery, Takahiro Clinic , Nishinomiya, Hyogo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"2025102810321967800_ref1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/ggi.13118","article-title":"Redefining the elderly as aged 75 years and older: proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society","volume":"17","author":"Ouchi","year":"2017","journal-title":"Geriatr Gerontol Int"},{"key":"2025102810321967800_ref2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s00774-009-0080-8","article-title":"Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis\/osteoporosis against disability study","volume":"27","author":"Yoshimura","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"2025102810321967800_ref3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1302\/0301-620X.89B4.18552","article-title":"Mortality and mobility after hip fracture in Japan: a ten-year follow-up","volume":"89-B","author":"Tsuboi","year":"2007","journal-title":"J Bone Joint Surg Br"},{"key":"2025102810321967800_ref4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2025102810321967800_ref5","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N Engl J Med"},{"key":"2025102810321967800_ref6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00774-013-0447-8","article-title":"Diagnostic criteria for primary osteoporosis: year 2012 revision","volume":"31","author":"Soen","year":"2013","journal-title":"J Bone Miner Metab"},{"key":"2025102810321967800_ref7","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 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