{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:14:26Z","timestamp":1766398466251,"version":"3.48.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanghai Municipal Health and Family Planning Commission Foundation","award":["201740224"],"award-info":[{"award-number":["201740224"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Proinflammatory substances from neutrophils play an essential role in gout flare. This study aimed to compare the levels of heparin-binding protein (HBP), released by neutrophils, among patients with gout, patients with osteoarthritis (OA), patients with asymptomatic hyperuricemia (HUA), and healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 102 patients diagnosed with gout, 26 patients with OA, 25 patients with asymptomatic HUA, and 23 HCs. Serum HBP was measured by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that the level of HBP was significantly elevated in patients experiencing gout flare compared with those in patients with relieving gout after taking nonsteroidal anti-inflammatory drugs (NSAIDs), patients with intercritical gout, and other control groups. Serum HBP was significantly different between patients who experienced gout relieving after NSAIDs and patients with intercritical gout. Receiver operating characteristic curve showed HBP could distinguish gout flare from relieving gout after NSAIDs. The area under the curve (AUC) was 0.8130, sensitivity was 0.9412, and specificity was 0.6286 at the cutoff HBP value of 42.09\u00a0ng\/ml. The HBP cutoff for differentiating relieving gout after NSAIDs from intercritical gout was 19.75\u00a0ng\/ml, which had an AUC of 0.8971, a sensitivity of 0.8485, and a specificity of 0.9118. Moreover, serum HBP levels were positive correlated with erythrocyte sedimentation rate, C-reactive protein, white blood cell, absolute neutrophil count, and neutrophil ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, our results showed elevated HBP levels in patients with gout flare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf063","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:19:54Z","timestamp":1751872794000},"page":"152-158","source":"Crossref","is-referenced-by-count":0,"title":["Elevated serum heparin-binding protein levels in patients with gout flare"],"prefix":"10.1093","volume":"36","author":[{"given":"Nana","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Huadong Hospital, Fudan University , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dahua Hospital , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"2025122205121850500_ref1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"2025122205121850500_ref2","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2478\/jtim-2022-0031","article-title":"Prevalence and risk factors of hyperuricemia and gout: a cross-sectional survey from 31 provinces in mainland China","volume":"10","author":"Song","year":"2022","journal-title":"J Transl Int Med"},{"key":"2025122205121850500_ref3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.puhe.2020.06.029","article-title":"Gout in China, 1990-2017: the global burden of disease study 2017","volume":"191","author":"Tang","year":"2021","journal-title":"Public Health"},{"key":"2025122205121850500_ref4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/2047487313514895","article-title":"Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis","volume":"22","author":"Clarson","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"2025122205121850500_ref5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s11906-020-01116-3","article-title":"Management of hyperuricemia in patients with chronic kidney disease: a focus on renal protection","volume":"22","author":"Kielstein","year":"2020","journal-title":"Curr Hypertens Rep"},{"key":"2025122205121850500_ref6","doi-asserted-by":"publisher","first-page":"e012020","DOI":"10.1161\/JAHA.119.012020","article-title":"Cohort study of repeated measurements of serum urate and risk of incident atrial fibrillation","volume":"8","author":"Li","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2025122205121850500_ref7","doi-asserted-by":"publisher","first-page":"E597","DOI":"10.1503\/cmaj.180717","article-title":"Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy","volume":"191","author":"Sultan","year":"2019","journal-title":"CMAJ."},{"key":"2025122205121850500_ref8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","article-title":"Asymptomatic hyperuricemia. 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