{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:49:53Z","timestamp":1776232193401,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To clarify contemporary epidemiological and clinical trends of Beh\u00e7et\u2019s disease in Japan by analysing the 2019 National Database of Designated Intractable Diseases (MHLW), describing patient demographics, organ involvement, impact on daily life, and treatment patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analysed the 2019 data from the National Database of Designated Intractable Diseases of Japan, provided by the Japanese Ministry of Health, Labour and Welfare. We focused on age distribution, symptom frequency, daily life impact, and treatment trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 2019 database, 10\u2009406 patients with BD were registered. The median age was 55\u00a0years, with a higher proportion of women affected (53.2%). Serious manifestations such as ocular, vascular, and central nervous system involvement were more frequent in males, whereas females showed more mucocutaneous and articular symptoms, representing mild forms of the disease. Pharmacological treatment was common (93.8%), with corticosteroids (44.3%), colchicine (50.9%), infliximab (17.0%), and adalimumab (9.6%) being frequently used. BD significantly affected daily life, with nearly one-third experiencing impaired mobility or depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide analysis highlighted sex-based differences in clinical features and found that BD continues to substantially affect quality of life. The widespread use of biologics suggests a shift in therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf103","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:24:57Z","timestamp":1760959497000},"page":"422-429","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological and clinical insights into Beh\u00e7et's disease in Japan: a 2019 nationwide analysis"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-0659","authenticated-orcid":false,"given":"Yuki","family":"Mizuki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]},{"name":"Department of Ophthalmology, Yokohama Minami Kyosai Hospital , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-0340","authenticated-orcid":false,"given":"Nobuyuki","family":"Horita","sequence":"additional","affiliation":[{"name":"Chemotherapy Center, Yokohama City University Hospital , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-7046","authenticated-orcid":false,"given":"Mitsuhiro","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Musashi Kosugi Hospital , Kawasaki ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Meguro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-661X","authenticated-orcid":false,"given":"Yohei","family":"Kirino","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsukata","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]},{"name":"Department of Ophthalmology, Dokkyo Medical University , Tochigi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuto","family":"Sakono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Mizuki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama 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