{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:24:30Z","timestamp":1790029470829,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the risk factors and prognosis of non-spontaneously regressing immunodeficiency-associated lymphoproliferative disorders (LPDs) after methotrexate (MTX) discontinuation in patients with rheumatoid arthritis (RA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed medical records of 38 patients with MTX-associated LPD and compared the characteristics of those with and without spontaneous regression (SR) of LPDs (SR versus non-SR groups: N\u2009=\u200922 versus 16) and of survivors and non-survivors in the non-SR group (N\u2009=\u20095 deaths).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SR and non-SR groups were comparable regarding age, sex, RA duration and activity, MTX use duration and dose, LPD stage and histological characteristics (lymphoma types and Epstein\u2013Barr encoding region in situ hybridisation positivity). However, the non-SR group had significantly higher lactate dehydrogenase (LDH) levels at LPD diagnosis and lower lymphocyte recovery 1\u00a0month after MTX withdrawal. Multivariate analysis revealed poor lymphocyte recovery 1\u00a0month after MTX withdrawal as a risk factor for non-SR (odds ratio: 7.12; P =\u2009.02). Log-rank test showed that elevated LDH levels (&amp;gt;250\u00a0U\/L) were significantly associated with death (P =\u2009.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lack of lymphocyte recovery 1\u00a0month after MTX discontinuation was a risk factor for non-spontaneously regressive LPD. High LDH level was associated with death in these cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf115","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:10:03Z","timestamp":1765285803000},"page":"359-366","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and prognosis of non-spontaneously regressing immunodeficiency-associated lymphoproliferative disorders in patients with rheumatoid arthritis after methotrexate discontinuation"],"prefix":"10.1093","volume":"36","author":[{"given":"Miyu","family":"Wakatsuki","sequence":"first","affiliation":[{"name":"Division of Rheumatic Diseases, National Centre for Global Health and Medicine , Shinjuku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-1941","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Rheumatic Diseases, National Centre for Global Health and Medicine , Shinjuku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Centre for Global Health and Medicine , Shinjuku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Rheumatic Diseases, National Centre for Global Health and Medicine , Shinjuku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"2026041500572343700_ref1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3899\/jrheum.140533","article-title":"Incidence of malignancy and the risk of lymphoma in Japanese patients with rheumatoid arthritis compared with the 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