{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:14:41Z","timestamp":1783332881330,"version":"3.54.6"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to follow patients classified as probable Beh\u00e7et\u2019s disease (BD) prospectively, conducting an inception cohort with patients diagnosed only within the last 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 55 patients with probable BD. Fulfilment of classification criteria, new major organ involvement, and immunosuppressive (IS) usage were assessed during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Initially, no patient fulfilled the International Study Group criteria. The median follow-up duration was 48 (21\u201377.5) months. Initially, 45 (81.8%) patients had major organ involvement. In 51 (92.7%) patients, bilateral common femoral vein wall thickness exceeded the 0.5\u00a0mm cut-off (Bilateral median common femoral vein wall thickness: 0.7\u00a0mm (0.70\u20130.80)). During follow-up, new major organ involvement was observed in 16 (29.1%) patients who needed step-up treatment with ISs. Six patients (10.9%) also developed new symptoms and subsequently fulfilled one or more diagnostic criteria. Two (3.6%) patients with pulmonary artery aneurysm had deceased due to massive haemoptysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>According to the 48-month follow-up results of the probable BD inception cohort, the majority of BD patients who had limited clinical findings started with major organ involvement. Only six (10.9%) patients developed new manifestations during follow-up, and these patients subsequently met the International Study Group and\/or International Criteria for Beh\u00e7et\u2019s Disease criteria. Additionally, 16 patients (29.1%) experienced new or relapsed major organ involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key messages<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roaf123","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:11:35Z","timestamp":1765458695000},"page":"641-647","source":"Crossref","is-referenced-by-count":0,"title":["Prospective follow-up of patients with probable Beh\u00e7et\u2019s disease: first results of an inception cohort"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1295-8739","authenticated-orcid":false,"given":"\u00d6zge","family":"Karak\u00f6k","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Kutlu\u011f-A\u011fa\u00e7k\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Ergelen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclin","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-1758","authenticated-orcid":false,"given":"Fatma","family":"Alibaz-Oner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"2026070605220643600_ref1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/1744666X.2016.1205486","article-title":"Behcet's disease: epidemiology, clinical manifestations, and diagnosis","volume":"13","author":"Davatchi","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"2026070605220643600_ref2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005792-200301000-00006","article-title":"The long-term mortality and morbidity of Beh\u00e7et syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center","volume":"82","author":"Kural-Seyahi","year":"2003","journal-title":"Medicine"},{"key":"2026070605220643600_ref3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrrheum.2017.208","article-title":"Beh\u00e7et syndrome: a contemporary view","volume":"14","author":"Yazici","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2026070605220643600_ref4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/diagnostics13010041","article-title":"Update on the diagnosis of Beh\u00e7et\u2019s disease","volume":"13","author":"Alibaz-Oner","year":"2022","journal-title":"Diagnostics"},{"key":"2026070605220643600_ref5","doi-asserted-by":"crossref","first-page":"103487","DOI":"10.1016\/j.autrev.2023.103487","article-title":"Relevance of vein wall thickness in Behcet's disease: a systematic review and meta-analysis","volume":"23","author":"Merashli","year":"2023","journal-title":"Autoimmun Rev"},{"key":"2026070605220643600_ref6","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. 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