{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:18:41Z","timestamp":1788175121980,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rituximab (RTX) is a standard maintenance therapy for antineutrophil cytoplasmic antibody-associated vasculitis. Its efficacy in Japan remains unclear, where microscopic polyangiitis (MPA) predominates and clinical characteristics differ from Western-dominated randomized controlled trial (RCT) populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Japanese patients with MPA or granulomatosis with polyangiitis (GPA) enrolled in a nationwide registry were included. Exposure was RTX use during maintenance therapy. The primary endpoint was major relapse\u2013free survival at 104\u00a0weeks. The secondary endpoint was any relapse\u2013free survival (major or minor) at 104\u00a0weeks. Baseline differences were adjusted using inverse probability of treatment weighting based on key demographic and disease-related covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 389 patients were analysed, with 85 in the RTX group. The RTX group included a higher proportion of GPA cases (37\/85 vs. 74\/304), resulting in baseline imbalance. After inverse probability of treatment weighting, no major relapses were observed in the RTX group, whereas the major relapse\u2013free survival at 104\u00a0weeks was 94.8% in the non-RTX group. The RTX group showed significantly higher any relapse\u2013free survival at 104\u00a0weeks (95.4% versus 83.3%; HR for any relapse, 0.27; 95% CI, 0.09\u20130.74; P\u2009=\u2009.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that RTX may be an effective option for remission maintenance in Japanese patients with MPA or GPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag014","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:44:03Z","timestamp":1771418643000},"page":"786-793","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and safety of rituximab for remission maintenance therapy in microscopic polyangiitis and granulomatosis with polyangiitis in Japan: A retrospective multicentre cohort study (J-CANVAS)"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4973-5823","authenticated-orcid":false,"given":"Motoki","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-2868","authenticated-orcid":false,"given":"Yoshiyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-2844","authenticated-orcid":false,"given":"Ayako","family":"Makiyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-879X","authenticated-orcid":false,"given":"Masahiro","family":"Kogami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-2044","authenticated-orcid":false,"given":"Satoshi","family":"Omura","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-9799","authenticated-orcid":false,"given":"Daiki","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Yamanashi Hospital , Yamanashi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Center for Rheumatic Disease, Japanese Red Cross Society Kyoto Daiichi Hospital , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-3537","authenticated-orcid":false,"given":"Naoho","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Chubu Rosai Hospital , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-6273","authenticated-orcid":false,"given":"Atsushi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Immuno-Rheumatology Center, St. Luke's International Hospital , Tokyo 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Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]},{"name":"Department of Hematology and Rheumatology, Kagoshima University Hospital , Kagoshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of General internal medicine, Tottori Red Cross Hospital , Tottori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-9943","authenticated-orcid":false,"given":"Shintaro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital , Hiroshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-4172","authenticated-orcid":false,"given":"Kiyoshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University , Nishinomiya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-929X","authenticated-orcid":false,"given":"Tohru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-7106","authenticated-orcid":false,"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki ,","place":["Japan"]},{"name":"Department of Rheumatology, Shimane University Faculty of Medicine , Izumo 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