{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:49:41Z","timestamp":1791222581759,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This multicentre cohort study aimed to describe the clinical and demographic features of paediatric patients diagnosed with chronic non-bacterial osteomyelitis in Turkey and to identify patient clusters based on bone involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 334 paediatric chronic non-bacterial osteomyelitis patients from 21 paediatric rheumatology centres were included. Data on clinical presentation, imaging, and biopsy results were collected. A two-step cluster analysis was performed to classify patients by bone-site involvement, resulting in four distinct clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Axial-thoracic cluster, involving the vertebra, clavicle, and sternum, was more common in female patients and showed higher rates of skin involvement. Lower-extremity cluster, characterized by lower extremity bone involvement, included the largest number of patients. Unlike previous reports, the Turkish cohort had a higher proportion of male patients and a lower frequency of skin involvement. At a median follow-up of 42.4\u00a0months, 77.3% of patients achieved remission, while 22% experienced a relapse. Mandibular involvement, additional rheumatologic diseases, and localized bone pain were associated with an increased relapse risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the clinical profile of paediatric chronic non-bacterial osteomyelitis in Turkey, marked by male predominance and low skin involvement. The identified bone-site clusters may help guide prognosis and should be validated in other populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag019","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:41:08Z","timestamp":1772196068000},"page":"845-851","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of 334 paediatric chronic non-bacterial osteomyelitis cases: A multicentre cohort study defining clusters"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0930","authenticated-orcid":false,"given":"\u00d6zge","family":"Ba\u015faran","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Hacettepe University , Ankara ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u011fmur","family":"Bay\u0131nd\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Hacettepe 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