{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:17:17Z","timestamp":1790281037564,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0109638"],"award-info":[{"award-number":["JP23ek0109638"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0410081"],"award-info":[{"award-number":["JP20ek0410081"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine whether interferon regulatory factor 5 (IRF5) activation and its temporal dynamics in immune cells correlate with disease activity and flares in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SLE were prospectively enrolled and followed up for 52\u00a0weeks. The IRF5 nuclear translocation rate (NTR) was assessed in monocytes, dendritic cells, and B cells during baseline and follow-ups. Associations among IRF5 NTR, disease activity, and flares were statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 40 patients enrolled, 27 were included in the analysis after meeting all inclusion criteria. Baseline IRF5 NTR in B cells was correlated with SLE disease activity index scores (r\u2009=\u20090.529, P\u2009=\u2009.005). Nineteen patients developed flares, and a high baseline IRF5 NTR showed good predictive accuracy (AUC\u2009=\u20090.763) and an increased flare risk (OR\u2009=\u200925.5, P\u2009=\u2009.003). In survival analysis, patients with a high IRF5 NTR had significantly shorter flare-free survival (log-rank P\u2009=\u2009.030) and a higher hazard of flare (HR\u2009=\u20097.43, P\u2009=\u2009.010). The IRF5 NTR further increased during the 12\u00a0weeks preceding flares (P\u2009=\u2009.040).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IRF5 NTR in B cells is a potential biomarker for disease activity and flare prediction in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag024","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:46:31Z","timestamp":1773233191000},"source":"Crossref","is-referenced-by-count":1,"title":["Predictive value of interferon regulatory factor 5 nuclear translocation in B cells for disease activity and flare in systemic lupus erythematosus: A prospective observational cohort study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-386X","authenticated-orcid":false,"given":"Yoshiro","family":"Kanayama","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Kitasato University School of Medicine , Sagamihara ,","place":["Japan"]},{"name":"Department of Immunology, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-9661","authenticated-orcid":false,"given":"Tatsuma","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Immunology, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go R","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Immunology, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]},{"name":"Laboratory for Immunotherapy , RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Arinuma","sequence":"additional","affiliation":[{"name":"Center for Rheumatic Diseases, Mie University Hospital , Tsu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Matsueda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kitasato University School of Medicine , Sagamihara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8858-9435","authenticated-orcid":false,"given":"Kunihiro","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kitasato University School of Medicine , Sagamihara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-1747","authenticated-orcid":false,"given":"Tomohiko","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Immunology, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]},{"name":"Advanced Medical Research Center, Yokohama City University , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026080306213953800_ref1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J Med"},{"key":"2026080306213953800_ref2","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/rheumatology\/keh397","article-title":"Health-related quality of life in Italian patients with systemic lupus erythematosus. 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