{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:48:07Z","timestamp":1785754087043,"version":"3.56.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To disentangle the contributions of three temporal factors\u2014onset-age, onset-era, and ageing\u2014to organ damage in systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 1228 patients with SLE from a nationwide registry in Japan whose disease onset occurred between 1990 and 2019 at \u226450\u00a0years of age. Organ damage was assessed using the Systemic Lupus International Collaborating Clinics\/American College of Rheumatology Damage Index (SDI) between 2020 and 2023. Negative binomial and logistic regression models estimated the independent associations of onset-age (&amp;lt;20\u00a0years [early-onset SLE: EOSLE] versus 20\u201350\u00a0years), onset-era (5-year ordinal categories), and current age with SDI outcomes, adjusting for sex and comorbidities. Pairwise interactions among the temporal factors were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EOSLE (count ratio 1.35; 95% confidence interval [95%CI] 1.05\u20131.75), past onset-eras (count ratio 1.10; 95%CI 1.03\u20131.18), and older age (count ratio 1.02; 95%CI 1.01\u20131.03) were independently associated with higher SDI. EOSLE and older age were also associated with SDI \u22651, while past onset-eras were associated with greater 1-year increases in SDI. There was no evidence of interactions among the three temporal factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Onset-age, onset-era, and ageing each exert distinct impact on organ damage in SLE. Recognizing these temporal aspects may strengthen risk stratification and individualized long-term care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag042","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:58:34Z","timestamp":1778673514000},"source":"Crossref","is-referenced-by-count":0,"title":["Disentangling temporal factors in organ damage accrual in systemic lupus erythematosus: Onset-age, onset-era, and ageing in the Japanese LUNA registry"],"prefix":"10.1093","author":[{"given":"Risa","family":"Sagawa","sequence":"first","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-8352","authenticated-orcid":false,"given":"Takashi","family":"Kida","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Rheumatic diseases, Graduate School of Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ei","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Kochi Medical School, Kochi University , Nankoku ,","place":["Japan"]},{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of medicine, Dentistry and pharmaceutical Sciences , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki ,","place":["Japan"]},{"name":"Department of Rheumatology, Shimane University Faculty of Medicine , Izumo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Yoshimi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine , Yokohama ,","place":["Japan"]},{"name":"Clinical Laboratory Department, Yokohama City University Hospital , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ohno","sequence":"additional","affiliation":[{"name":"Center for Rheumatic Diseases, Yokohama City University Medical Center , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Kawamori","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Showa Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine , Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine , Matsumoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Yokohama Rosai Hospital , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshia","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of medicine, Dentistry and pharmaceutical Sciences , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Kyosai Hospital , Tokyo ,","place":["Japan"]},{"name":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (Tokyo Medical and Dental University) , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Takatani","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki ,","place":["Japan"]},{"name":"Rheumatic Disease Center, Sasebo Chuo Hospital , Sasebo ,","place":["Japan"]},{"name":"Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kakogawa Central City Hospital , Kakogawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine , Kobe ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Chiba University Hospital , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto 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Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-0488","authenticated-orcid":false,"given":"Yutaka","family":"Kawahito","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"2026080306213942600_ref1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/ard-2022-223741","article-title":"Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets","volume":"82","author":"Crow","year":"2023","journal-title":"Ann Rheum 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