{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:50:01Z","timestamp":1792457401192,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["23K07876"],"award-info":[{"award-number":["23K07876"]}]},{"name":"Ministry of Health, Labour and Welfare Research Program on Rare and Intractable Diseases","award":["JPMH26FC10-19"],"award-info":[{"award-number":["JPMH26FC10-19"]}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>&amp;gt;Objectives<\/jats:title>\n                    <jats:p>Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder affecting multiple organs, but the extent to which immune microenvironments differ across tissues remains unclear. We compared immune cell compositions between submandibular gland and pancreatic lesions using transcriptome-based deconvolution analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>&amp;gt;Methods<\/jats:title>\n                    <jats:p>Bulk RNA sequencing data were obtained from patients with IgG4-related submandibular sialadenitis (n\u2009=\u200940) and autoimmune pancreatitis (n\u2009=\u20098). Immune cell fractions were estimated using CIBERSORTx with the LM22 immune signature matrix. Relative immune cell compositions were compared descriptively, and exploratory Mann\u2013Whitney U tests with false discovery rate adjustment were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>&amp;gt;Results<\/jats:title>\n                    <jats:p>Both tissues shared broad immune cell repertoires, including B cells, T cells, macrophages, dendritic cells, mast cells, and natural killer cells, indicating a common immune framework across IgG4-RD lesions. However, organ-specific differences in relative immune cell abundance were observed. Pancreatic lesions showed a tendency toward increased macrophage populations, particularly M1-like macrophages, together with relatively reduced na\u00efve B-cell fractions. In contrast, submandibular gland lesions demonstrated relatively enriched B-cell populations, including na\u00efve and memory B cells, with a more balanced macrophage distribution. These patterns were consistently observed across samples and supported by deconvolution confidence metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>&amp;gt;Conclusions<\/jats:title>\n                    <jats:p>IgG4-RD lesions share common immunological features while exhibiting differences in relative immune cell composition across tissues. Pancreatic lesions tended to show relatively increased macrophage fractions, whereas submandibular gland lesions demonstrated a more lymphocyte-rich immune profile. These findings suggest that local tissue context may shape immune composition and contribute to clinical heterogeneity in IgG4-RD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag057","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:05:34Z","timestamp":1782590734000},"source":"Crossref","is-referenced-by-count":2,"title":["Exploratory comparison of immune cell compositions across organs in immunoglobulin G4-related disease"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-2484","authenticated-orcid":false,"given":"Motohisa","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-947X","authenticated-orcid":false,"given":"Ryuta","family":"Kamekura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-5918","authenticated-orcid":false,"given":"Masaaki","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7334-5714","authenticated-orcid":false,"given":"Yuta","family":"Ichii","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-6710","authenticated-orcid":false,"given":"Yujiro","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6633-7250","authenticated-orcid":false,"given":"Keisuke","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine , Sapporo 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