{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:25:06Z","timestamp":1787318706288,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Labour and Welfare Research Program on Rare and Intractable Diseases","award":["JPMH23FC1015"],"award-info":[{"award-number":["JPMH23FC1015"]}]},{"name":"JSPS KAKENHI","award":["23\u00a0K07876"],"award-info":[{"award-number":["23\u00a0K07876"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify therapeutic candidates for Immunoglobulin (Ig)G4-related sialadenitis, a manifestation of IgG4-related disease characterized by IgG4-positive plasma cell infiltration and limited treatment options beyond glucocorticoids, using transcriptomic profiling and in silico drug repurposing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Submandibular gland tissues from 49 patients with IgG4-related sialadenitis and 3 controls were analysed by RNA sequencing. Differentially expressed genes were screened against DrugBank to identify druggable targets. Candidate drugs were prioritized based on their ability to modulate disease-associated gene signatures. Molecular docking was performed to evaluate binding affinities to key targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transcriptomic analysis revealed upregulation of immune-related pathways. DrugBank integration identified fostamatinib as a top candidate targeting multiple kinases, including spleen tyrosine kinase (SYK), Bruton\u2019s tyrosine kinase (BTK), and Janus kinase 3. Docking analysis demonstrated favourable binding affinity, particularly to BTK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This integrative approach highlights fostamatinib as a promising therapeutic candidate and supports a role for the SYK\u2013BTK axis in IgG4-RD pathogenesis, suggesting a potential alternative to glucocorticoids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag059","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:53:13Z","timestamp":1783684393000},"source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic profiling and drug repurposing identify fostamatinib as a candidate therapeutic agent for IgG4-related sialadenitis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-2484","authenticated-orcid":false,"given":"Motohisa","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-947X","authenticated-orcid":false,"given":"Ryuta","family":"Kamekura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine , Hokkaido ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-5918","authenticated-orcid":false,"given":"Masaaki","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7334-5714","authenticated-orcid":false,"given":"Yuta","family":"Ichii","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Clinical Immunology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-6384","authenticated-orcid":false,"given":"Kenichi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine , Hokkaido 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