{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:59:47Z","timestamp":1791464387349,"version":"4.3.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K19239"],"award-info":[{"award-number":["24K19239"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate the association between specific autoantibodies and cardiac arrhythmias in Japanese patients with systemic sclerosis (SSc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Arrhythmias in patients with SSc treated at Kyoto University Hospital were retrospectively analysed, focusing on anti-topoisomerase I antibody, anti-centromere antibody, anti-RNA polymerase III, and anti-U1-ribonucleoprotein. Logistic regression analyses were performed to assess the relationships between autoantibodies and arrhythmias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cardiac arrhythmias were observed in 153 of 389 SSc patients (39%), including premature atrial contraction (25.2%), premature ventricular contraction (23.9%), atrial fibrillation (4.6%), atrial tachycardia\/atrial flutter (1.5%), ventricular tachycardia\/ventricular fibrillation (0.3%), bradyarrhythmia (5.9%), and pacemaker implantation (1.5%) during a 12.62\u2009\u00b1\u20091.06-year observation periods. The highest frequency was observed in anti-RNA polymerase III (42.4%), followed by anti-topoisomerase I antibody (38.7%), anti-centromere antibody (35.8%), and anti-U1-ribonucleoprotein (30.0%). After age- and sex-adjustment, anti-centromere antibody was negatively associated with the occurrence of arrhythmia (odds ratio\u2009=\u20090.51, P\u2009=\u2009.007), especially premature atrial contraction (odds ratio\u2009=\u20090.47, P\u2009=\u2009.004) among patients with SSc. Conversely, anti-U1-ribonucleoprotein was positively associated with atrial fibrillation (odds ratio\u2009=\u20094.7, P\u2009=\u2009.04). There were no significant differences in the frequencies of premature ventricular contraction, atrial tachycardia\/atrial flutter, ventricular tachycardia\/ventricular fibrillation, or tachyarrhythmias overall among autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct SSc-related autoantibodies are differentially associated with the occurrence of arrhythmias, suggesting that autoantibody profiles influence arrhythmic risk in SSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roag082","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:35:05Z","timestamp":1789673705000},"source":"Crossref","is-referenced-by-count":0,"title":["The association between cardiac arrhythmia and autoantibodies in systemic sclerosis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-8434","authenticated-orcid":false,"given":"Tsubasa","family":"Betsuyaku","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-246X","authenticated-orcid":false,"given":"Hideaki","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]},{"name":"Department of Rheumatology, Kobe City Medical Center General Hospital , Kobe ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-0463","authenticated-orcid":false,"given":"Mirei","family":"Shirakashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-5712","authenticated-orcid":false,"given":"Ryosuke","family":"Hiwa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8056-8648","authenticated-orcid":false,"given":"Koji","family":"Kitagori","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University 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