{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:57:51Z","timestamp":1789106271246,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Anti-PM\/Scl antibodies are associated with the overlap syndrome of systemic sclerosis and dermatomyositis\/polymyositis (SSc-DM\/PM), and are found in 50% of SSc-DM\/PM cases in Europe and the USA, whereas they are rare in Japan. We report a case of an 80-year-old Japanese female with SSc-amyopathic dermatomyositis overlap syndrome, who developed scleroderma renal crisis, a complication of SSc. She had positive antinuclear antibodies in a discrete-speckled and nucleolar pattern and anti-centromere antibodies and anti-PM\/Scl antibodies were confirmed by enzyme-linked immunosorbent assay and immunoprecipitation, respectively. The incidence rate of SRC in SSc patients varies significantly depending on the specificity of autoantibodies, with the highest incidence of \u223c50% in anti-RNA polymerase III antibody positive patients, followed by \u223c10% in anti-PM\/Scl and lower incidence of 0.45% in anti-centromere antibody-positive cases. Anti-PM\/Scl antibodies are uncommon in Japanese patients presumably due to its strong association with certain human leucocyte antigen haplotype that is rare in Japanese. Clinical significance of anti-PM\/Scl antibodies in Japanese patients will need to be clarified with accumulation of cases in future studies.<\/jats:p>","DOI":"10.1093\/mrcr\/rxab025","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T17:17:54Z","timestamp":1631294274000},"page":"69-74","source":"Crossref","is-referenced-by-count":3,"title":["A Japanese patient with anti-PM\/Scl and centromere antibody-positive scleroderma-amyopathic dermatomyositis overlap syndrome who developed renal crisis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-2268","authenticated-orcid":false,"given":"Tomoya","family":"Nishida","sequence":"first","affiliation":[{"name":"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan"},{"name":"Department of Medicine and Biosystemic Science, Kyushu University Faculty of Medicine, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-2997","authenticated-orcid":false,"given":"Kazuhisa","family":"Nakano","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan"},{"name":"Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Fukuyo","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Kyushu University Faculty of Medicine, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-7139","authenticated-orcid":false,"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"2022011123194866800_R1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF00915286","article-title":"Antibodies to a nuclear\/nucleolar antigen in patients with polymyositis overlap syndromes","volume":"4","author":"Reichlin","year":"1984","journal-title":"J Clin Immunol"},{"key":"2022011123194866800_R2","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-015-0573-x","article-title":"Anti-PM\/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma","volume":"17","author":"Muro","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"2022011123194866800_R3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2022011123194866800_R4","first-page":"1281","article-title":"Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis","volume":"22","author":"Clements","year":"1995","journal-title":"J Rheumatol"},{"key":"2022011123194866800_R5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/rheumatology\/keh156","article-title":"Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis","volume":"43","author":"Cutolo","year":"2004","journal-title":"Rheumatology"},{"key":"2022011123194866800_R6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/qjmed\/hcm052","article-title":"Scleroderma renal crisis: patient characteristics and long-term outcomes","volume":"100","author":"Penn","year":"2007","journal-title":"QJM"},{"key":"2022011123194866800_R7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12185-017-2264-7","article-title":"For TTP group of blood coagulation abnormalities research team, research on rare and intractable disease supported by health, labour, and welfare sciences research grants. 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