{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:33:02Z","timestamp":1771543982294,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A 53-year-old woman with a 6-year history of rheumatoid arthritis (RA) presented with pharyngeal pain, fever, and altered mental status. The patient had been treated with methotrexate (MTX) 12\u2009mg\/week, baricitinib 4\u2009mg\/day, and tacrolimus 2\u2009mg\/day. Magnetic resonance imaging of the brain revealed diffuse high-intensity lesions in the cerebral white matter, basal ganglia, brainstem, and right cerebellar hemisphere. She was diagnosed with Epstein-Barr virus (EBV) encephalitis due to elevated levels of EBV-DNA in the cerebrospinal fluid and serum. Although MTX-associated lymphoproliferative disorders are well-known complications in patients with RA, EBV encephalitis requires careful attention for such patients undergoing treatment with multiple potent immunosuppressants.<\/jats:p>","DOI":"10.1093\/mrcr\/rxab045","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T16:09:41Z","timestamp":1640966981000},"page":"160-162","source":"Crossref","is-referenced-by-count":8,"title":["Epstein-Barr virus encephalitis in a patient with rheumatoid arthritis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-3740","authenticated-orcid":false,"given":"Jun","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-6774","authenticated-orcid":false,"given":"Takao","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University , Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"2022062410203904200_R1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00019052-200006000-00012","article-title":"Epstein-Barr virus and the nervous system","volume":"13","author":"Portegies","year":"2000","journal-title":"Curr Opin Neurol"},{"key":"2022062410203904200_R2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/IJGM.S143335","article-title":"Encephalitis treatment - 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