{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:30:35Z","timestamp":1769607035049,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Coronavirus disease 2019 (COVID-19) vaccines have some adverse effects, mostly mild. However, by presenting an immunological challenge to the individual, they could infrequently trigger immune-mediated diseases (IMDs). We report the case of a 42-year-old woman, with no previous medical history, who received the first dose of vaccine against COVID-19 and developed inflammatory arthralgias, associated with sudden-onset dyspnoea and hypoxemia. Pulmonary thromboembolism was documented, and the diagnosis of systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) was suspected. Autoantibodies were measured confirming this suspicion. After a few days, she presented a massive pericardial effusion with cardiac tamponade that required surgical management. Treatment with azathioprine, hydroxychloroquine, corticosteroids, and anticoagulation was indicated with improvement of all her symptoms. There is controversy regarding the potential of COVID-19 vaccines to induce autoimmunity. Studies addressing the safety of using these vaccines have reported the occurrence of mild local and systemic reactions, most frequently in young adults. So far, there are few reports of patients who have developed autoimmune or autoinflammatory diseases after getting vaccinated with any of the COVID-19 vaccines. To the best of our knowledge, to date, this is one of the first cases of new-onset SLE and secondary APS after COVID-19 vaccination.<\/jats:p>","DOI":"10.1093\/mrcr\/rxac018","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T02:00:31Z","timestamp":1646445631000},"page":"43-46","source":"Crossref","is-referenced-by-count":32,"title":["Systemic lupus erythematosus and antiphospholipid syndrome after COVID-19 vaccination. A case report"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-8198","authenticated-orcid":false,"given":"Sebastian","family":"Molina-Rios","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia , Carrera 30 No. 45-03, Bogot\u00e1 DC 111321, Colombia"},{"name":"Rheumatology Unit, Department of Internal Medicina, Hospital Universitario Nacional de Colombia , Calle 44 No. 59-75, Bogot\u00e1 DC 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigoberto","family":"Rojas-Martinez","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia , Carrera 30 No. 45-03, Bogot\u00e1 DC 111321, Colombia"},{"name":"Rheumatology Unit, Department of Internal Medicina, Hospital Universitario Nacional de Colombia , Calle 44 No. 59-75, Bogot\u00e1 DC 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Marcela","family":"Est\u00e9vez-Ramirez","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia , Carrera 30 No. 45-03, Bogot\u00e1 DC 111321, Colombia"},{"name":"Rheumatology Unit, Department of Internal Medicina, Hospital Universitario Nacional de Colombia , Calle 44 No. 59-75, Bogot\u00e1 DC 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimy Francisco","family":"Medina","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia , Carrera 30 No. 45-03, Bogot\u00e1 DC 111321, Colombia"},{"name":"Rheumatology Unit, Department of Internal Medicina, Hospital Universitario Nacional de Colombia , Calle 44 No. 59-75, Bogot\u00e1 DC 111321, 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