{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:59:00Z","timestamp":1754600340762,"version":"3.37.3"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Beh\u00e7et\u2019s disease (BD) is often associated with neutrophilic dermatosis. However, BD is rarely associated with aseptic abscesses in the spleen or liver. A 2-year-old girl presented to our hospital with a 2-week history of fever, abdominal pain, and a skin ulcer on her leg. Each time her skin was punctured with a needle for a blood test or spinal fluid test, she developed intractable aseptic abscesses on her skin. She was diagnosed with intestinal BD based on gastrointestinal endoscopy findings and was treated with prednisolone, mesalazine, and elemental diet therapy. Although these were effective for her colon ulcers, low-grade fever and mild abdominal pain persisted. Abdominal computed tomography revealed a low-density area in the spleen. Although it is recommended to check the contents with puncture drainage, it was difficult due to the risk of bleeding and pathergy. The abscess expanded despite antimicrobial therapy. We discontinued antimicrobial therapy and switched to intensified immunosuppressive therapy for BD [intravenous infliximab (IFX)]. After administration of IFX, the splenic abscess gradually disappeared, and all her symptoms improved. In cases of BD with splenic abscesses resistant to antimicrobial therapy, intensifying immunosuppressive therapy can be expected to shrink the abscesses and avoid splenectomy.<\/jats:p>","DOI":"10.1093\/mrcr\/rxac020","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T12:52:29Z","timestamp":1647003149000},"page":"266-269","source":"Crossref","is-referenced-by-count":2,"title":["Successful management of a case of intestinal Beh\u00e7et\u2019s disease with a splenic abscess by intensified immunosuppressive therapy without splenectomy"],"prefix":"10.1093","volume":"6","author":[{"given":"Noriko","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-9710","authenticated-orcid":false,"given":"Fumiya","family":"Yamaide","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-1204","authenticated-orcid":false,"given":"Taiji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yamaide","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Chiba University , Chiba, Japan"},{"name":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"2022062410415964700_R1","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.3748\/wjg.v21.i13.3801","article-title":"Gastrointestinal Behcet\u2019s disease: a review","volume":"21","author":"Skef","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2022062410415964700_R2","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.3748\/wjg.v19.i20.3165","article-title":"Behcet\u2019s disease complicated by multiple aseptic abscesses of the liver and spleen","volume":"19","author":"Maeshima","year":"2013","journal-title":"World J Gastroenterol"},{"key":"2022062410415964700_R3","first-page":"70","article-title":"A case of intestinal Behcet\u2019s disease with pyoderma gangrenosum intially treated as Sweet\u2019s syndrome (in Japanese)","volume":"9","author":"Sato","year":"2018","journal-title":"J Pediatr Rheumatol Assoc Jpn"},{"key":"2022062410415964700_R4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3748\/wjg.v12.i3.460","article-title":"Clinical characteristics and prognostic factors of splenic abscess: a review of 67 cases in a single medical center of Taiwan","volume":"12","author":"Chang","year":"2006","journal-title":"World J Gastroenterol"},{"key":"2022062410415964700_R5","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.3748\/wjg.14.3088","article-title":"Abscesses of the spleen: report of three cases","volume":"14","author":"Fotiadis","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2022062410415964700_R6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ejim.2009.04.009","article-title":"Splenic abscess: a review of 22 cases in a single institution","volume":"20","author":"Llenas","year":"2009","journal-title":"Eur J Intern Med"},{"key":"2022062410415964700_R7","first-page":"46","article-title":"A case of incompetent Behcet\u2019s disease complicated with splenic abscess (in Japanese)","volume":"41","author":"Ichisaka","year":"2017","journal-title":"Hakodate Igakushi"},{"key":"2022062410415964700_R8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.5217\/ir.2017.15.3.422","article-title":"Behcet\u2019s disease with multiple splenic abscesses in a child","volume":"15","author":"Lim","year":"2017","journal-title":"Intest Res"},{"key":"2022062410415964700_R9","article-title":"A case of Behcet\u2019s disease complicated with splenic abscess (in Japanese)","volume":"40","author":"Teduka","year":"2007","journal-title":"Jpn J Gastroenterol Surg"},{"key":"2022062410415964700_R10","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1607-551X(09)70499-1","article-title":"Splenic abscesses: review of 29 cases","volume":"19","author":"Chiang","year":"2003","journal-title":"Kaohsiung J Med Sci"},{"key":"2022062410415964700_R11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3349\/ymj.2011.52.2.288","article-title":"Splenic abscess: a single institution study and review of the literature","volume":"52","author":"Lee","year":"2011","journal-title":"Yonsei Med J"},{"key":"2022062410415964700_R12","first-page":"1","article-title":"Splenic abscess: an uncommon entity with potentially life-threatening evolution","volume":"2018","author":"Lee","year":"2018","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"2022062410415964700_R13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00000658-195208000-00006","article-title":"Splenic studies. I. Susceptibility to infection after splenectomy performed in infancy","volume":"136","author":"King","year":"1952","journal-title":"Ann Surg"},{"key":"2022062410415964700_R14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(10)61493-6","article-title":"Post-splenectomy and hyposplenic states","volume":"378","author":"Di Sabatino","year":"2011","journal-title":"Lancet"},{"key":"2022062410415964700_R15","first-page":"16","article-title":"Treatment and prevention for overwhelming postsplenectomy infection (OPSI) (in Japanese)","volume":"20","author":"Hashimoto","year":"2014","journal-title":"J Jpn Soc Portal Hypertens"},{"key":"2022062410415964700_R16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.epsc.2014.11.011","article-title":"A report of two cases of splenectomy in children younger than two years old with hereditary spherocytosis","volume":"3","author":"Jin","year":"2015","journal-title":"J Pediatr Surg Case Rep"},{"key":"2022062410415964700_R17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJMcp1314291","article-title":"Care of the asplenic patient","volume":"371","author":"Rubin","year":"2014","journal-title":"N Engl J Med"},{"key":"2022062410415964700_R18","first-page":"461","article-title":"The role and indication of splenectomy for hematological disorders in children (in Japanese)","volume":"17","author":"Horikoshi","year":"2003","journal-title":"Jpn J Pediatr Hematol"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxac020\/42992323\/rxac020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/6\/2\/266\/44245098\/rxac020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/6\/2\/266\/44245098\/rxac020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:42:30Z","timestamp":1656067350000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/6\/2\/266\/6547067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,3,11]]},"published-print":{"date-parts":[[2022,6,24]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxac020","relation":{},"ISSN":["2472-5625"],"issn-type":[{"type":"electronic","value":"2472-5625"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,3,11]]}}}