{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:25:16Z","timestamp":1751433916194,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Familial Mediterranean fever (FMF) is a hereditary auto-inflammatory disease resulting from mutations of the MEFV gene. The disease is characterised by recurrent attacks of abdominal pain and fever. Most FMF patients develop arthritis at some point in their life usually manifesting as self-limiting monoarthritis. On very rare occasions, arthritis in FMF can mimic septic arthritis (pseudo-septic arthritis) with very similar clinical and laboratory findings. We report a case of a young male patient who presented with recurrent attacks of prolonged monoarthritis. For 2\u2009years, he had undergone multiple admissions and operations for drainage of suspected septic joints. The synovial aspiration showed culture-negative pus with very high synovial white blood cell counts highly suggestive of septic arthritis. The patient was later found to have FMF based on homozygous M694V mutation of the MEFV gene. He was treated with colchicine monotherapy with a quick improvement of arthritis and later good control of his disease. The literature review showed very few case reports with similar presentations, most of which responded well to colchicine. FMF can mimic septic arthritis resulting in unnecessary expensive and invasive interventions and prolonged courses of antibiotics. Pseudo-septic arthritis is usually associated with M694V homozygous mutation and can complicate FMF at any time throughout the disease course. It is important to consider FMF in the differential diagnosis of septic arthritis, particularly with a family history of FMF and in patients from communities with a high prevalence of MEFV gene mutation.<\/jats:p>","DOI":"10.1093\/mrcr\/rxac040","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T02:25:50Z","timestamp":1652149550000},"page":"252-256","source":"Crossref","is-referenced-by-count":3,"title":["Familial Mediterranean fever with pseudo-septic arthritis: A case report and review of the literature"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-0835","authenticated-orcid":false,"given":"Laith","family":"Alamlih","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Immunology, Faculty of Medicine, Hebron University , Hebron, Palestine"},{"name":"Department of Rheumatology, Princess Alia Hospital , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layth","family":"AL-Karaja","sequence":"additional","affiliation":[{"name":"Department of Internal medicine, Princess Alia Hospital , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alayaseh","sequence":"additional","affiliation":[{"name":"Department of magnetic resonance imaging, Ibn-Rushd Radiology Center , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawzy","family":"Abunejma","sequence":"additional","affiliation":[{"name":"Division of Rheumatology,faculty of medicine, Alquds University , Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyad","family":"Al-Zeer","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Princess Alia Hospital , Hebron, 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