{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:16:45Z","timestamp":1740179805844,"version":"3.37.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Rheumatoid arthritis (RA) is an autoimmune disease involving synovial joints, and it is known that extra-articular manifestations that may affect the central and peripheral nervous systems may develop during its course. Rheumatoid meningitis is very rare among all neurological involvements. In this study, cases diagnosed as rheumatoid meningitis with clinical, imaging, laboratory, and histopathological features are presented, and the aim of the study is to present current approaches in the diagnosis and treatment of rheumatoid meningitis in the light of case studies and current literature. The data of the patients who were followed up with the diagnosis of rheumatoid meningitis in neurology clinic between 2017 and 2021 were reviewed retrospectively. Three cases diagnosed with rheumatoid meningitis are presented in detail. In the first case, the diagnosis was reached by clinical, imaging, and laboratory findings as well as treatment response, while the diagnosis was made by histopathological verification in the second case. The third case shows that spontaneous remission can be observed in the course of rheumatoid meningitis. Rheumatoid meningitis, which is one of the rarest involvements in the course of RA, may present with headaches, focal neurological deficits, seizures, and altered consciousness. A meningeal biopsy is recommended when the differential diagnosis cannot be ruled out with imaging and laboratory findings. In the differential diagnosis Mucobacterium tuberculosis, syphilis, neuro-sarcoidosis, immunoglobulin G4\u2013related disease, lymphoproliferative diseases, and systemic metastasis should be kept in mind. Aggressive RA management is recommended for treatment.<\/jats:p>","DOI":"10.1093\/mrcr\/rxad010","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T14:58:55Z","timestamp":1675177135000},"page":"340-346","source":"Crossref","is-referenced-by-count":2,"title":["A review of rheumatoid meningitis with case studies"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-8453","authenticated-orcid":false,"given":"Merve","family":"Aktan Suzgun","sequence":"first","affiliation":[{"name":"Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursena","family":"Erener","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokce Hande","family":"Cavus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Ozdede","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabriye","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdal","family":"Ugurlu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil","family":"Comunoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Kizilkilic","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabahattin","family":"Saip","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"2023061920013739400_R1","first-page":"286","article-title":"Extra-articular manifestations in rheumatoid arthritis","volume":"5","author":"Cojocaru","year":"2010","journal-title":"Maedica (Bucur)"},{"key":"2023061920013739400_R2","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1212\/WNL.0000000000000366","article-title":"Rheumatoid meningitis presenting with stroke-like episodes","volume":"82","author":"Bourgeois","year":"2014","journal-title":"Neurology"},{"key":"2023061920013739400_R3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/jcp.7.3.239","article-title":"Widespread serous membrane involvement by rheumatoid nodules","volume":"7","author":"Ellman","year":"1954","journal-title":"J Clin Pathol"},{"key":"2023061920013739400_R4","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1111\/ene.14904","article-title":"Rheumatoid meningitis: a systematic review and meta-analysis","volume":"28","author":"Villa","year":"2021","journal-title":"Eur J Neurol"},{"key":"2023061920013739400_R5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5152\/eurjrheum.2020.20063","article-title":"Leptomeningitis in rheumatoid arthritis","volume":"8","author":"Manolios","year":"2021","journal-title":"Eur J Rheumatol"},{"key":"2023061920013739400_R6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/practneurol-2018-001978","article-title":"Rheumatoid leptomeningitis presenting with an acute neuropsychiatric disorder","volume":"19","author":"Lubomski","year":"2019","journal-title":"Pract Neurol"},{"key":"2023061920013739400_R7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s10072-014-1699-3","article-title":"Parkinsonism as an initial manifestation of rheumatoid meningitis","volume":"35","author":"Hayashi","year":"2014","journal-title":"Neurol Sci"},{"key":"2023061920013739400_R8","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00163","article-title":"Rheumatoid meningitis presenting with acute parkinsonism and protracted non-convulsive seizures: an unusual case presentation and review of treatment strategies","volume":"10","author":"Pellerin","year":"2019","journal-title":"Front Neurol"},{"key":"2023061920013739400_R9","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1007\/s00296-011-2105-6","article-title":"Magnetic resonance imaging of rheumatoid meningitis: a case report and literature review","volume":"32","author":"Hasiloglu","year":"2012","journal-title":"Rheumatol Int"},{"key":"2023061920013739400_R10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-227905","article-title":"Rheumatoid meningitis: a rare cause of unilateral pachymeningitis","volume":"12","author":"Grose","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2023061920013739400_R11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000514728","article-title":"Secondary normal-pressure hydrocephalus in rheumatoid meningitis","volume":"13","author":"Owens","year":"2021","journal-title":"Case Rep Neurol"},{"key":"2023061920013739400_R12","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-226649","article-title":"Rheumatoid arthritis presenting as rheumatoid meningitis","volume":"12","author":"McKenna","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2023061920013739400_R13","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-229642","article-title":"Rheumatoid meningitis can present MRI findings that mimic chronic subdural haematoma","volume":"12","author":"Yagita","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2023061920013739400_R14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/20009666.2019.1593780","article-title":"When the plot thickens: a rare complication of rheumatoid arthritis","volume":"9","author":"Scheitel","year":"2019","journal-title":"J Community Hosp Intern Med Perspect."},{"key":"2023061920013739400_R15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/1941874419859769","article-title":"Rheumatoid meningitis: clinical characteristics, diagnostic evaluation, and treatment","volume":"10","author":"Parsons","year":"2020","journal-title":"Neurohospitalist"},{"key":"2023061920013739400_R16","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/s10165-009-0186-9","article-title":"Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis","volume":"19","author":"Shimada","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2023061920013739400_R17","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00666","article-title":"Use of cerebrospinal fluid biomarkers in diagnosis and monitoring of rheumatoid meningitis","volume":"10","author":"Nissen","year":"2019","journal-title":"Front Neurol"},{"key":"2023061920013739400_R18","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.2169\/internalmedicine.5016-20","article-title":"Anti-agalactosyl immunoglobulin G antibodies in probable rheumatoid meningitis","volume":"59","author":"Hatano","year":"2020","journal-title":"Intern Med"},{"key":"2023061920013739400_R19","first-page":"1","article-title":"A case of rheumatoid meningitis with elevated antibody titer indices of anti-cyclic citrullinated peptide antibody and anti-galactose-deficient IgG antibody","volume":"00","author":"Nakamura","year":"2021","journal-title":"Neurol Clin Neurosci"},{"key":"2023061920013739400_R20","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061625","article-title":"Rheumatoid meningitis a rare extra-articular manifestation of rheumatoid arthritis: report of 6 cases and literature review","volume":"9","author":"Trabelsi","year":"2020","journal-title":"J Clin Med"},{"key":"2023061920013739400_R21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5114\/reum.2020.95368","article-title":"Rheumatoid arthritis with pachymeningitis\u2014a case presentation and review of the literature","volume":"58","author":"Joshi","year":"2020","journal-title":"Reumatologia"},{"key":"2023061920013739400_R22","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-226642","article-title":"Rheumatoid meningitis: successful remission with rituximab","volume":"11","author":"Harrison","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2023061920013739400_R23","article-title":"Rheumatoid meningitis occurring during etanercept treatment","volume":"2017","author":"Tsuzaki","year":"2017","journal-title":"Case Rep Neurol Med"},{"key":"2023061920013739400_R24","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1007\/s00415-009-5286-0","article-title":"Infliximab in the treatment of rheumatoid meningoencephalitis","volume":"256","author":"Luessi","year":"2009","journal-title":"J Neurol"},{"key":"2023061920013739400_R25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.berh.2019.02.003","article-title":"Central nervous system involvement in rheumatoid arthritis patients and the potential implications of using biological agents","volume":"32","author":"Atzeni","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023061920013739400_R26","article-title":"Rheumatoid meningoencephalitis: a feared condition in the era of TNF blockers","volume":"2018","author":"Figueroa Rodriguez","year":"2018","journal-title":"Case Rep Rheumatol"},{"key":"2023061920013739400_R27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2165\/00002018-200427050-00003","article-title":"Safety of tumour necrosis factor-\u03b1 antagonists","volume":"27","author":"Khanna","year":"2004","journal-title":"Drug Saf"},{"key":"2023061920013739400_R28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00296-021-04822-6","article-title":"Aseptic meningitis in rheumatoid arthritis after anti-TNF administration: a case-based literature review","volume":"41","author":"Yildirim","year":"2021","journal-title":"Rheumatol Int"},{"key":"2023061920013739400_R29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11910-022-01173-y","article-title":"Granulomatous diseases of the central nervous system","volume":"22","author":"Dasovic","year":"2022","journal-title":"Curr Neurol Neurosci Rep"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxad010\/49234907\/rxad010.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/7\/2\/340\/50646483\/rxad010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/7\/2\/340\/50646483\/rxad010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T20:07:05Z","timestamp":1687205225000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/7\/2\/340\/7014781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,31]]},"published-print":{"date-parts":[[2023,6,19]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxad010","relation":{},"ISSN":["2472-5625"],"issn-type":[{"type":"electronic","value":"2472-5625"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,1,31]]}}}