{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:16:56Z","timestamp":1740179816594,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Patients with systemic lupus erythematosus (SLE) occasionally develop thrombotic thrombocytopenic purpura (TTP), which can be fatal. Here, we report a case of TTP developing 3\u2009years after SLE remitted with rituximab (RTX) therapy. A 50-year-old woman was treated with RTX for marked immune thrombocytopenic purpura and autoimmune haemolytic anaemia due to SLE relapse. After induction of remission, she was treated with prednisolone alone without maintenance therapy with RTX. Approximately 3\u2009years later, she was readmitted with marked thrombocytopenia and severe renal dysfunction. On admission, she was diagnosed with TTP for the first time based on severe reduction in a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity and detection of ADAMTS13 inhibitors. CD19+ B cells in the patient\u2019s serum increased to 34%, suggesting that B cells had reactivated once the effect of RTX had subsided. The patient was successfully treated with plasmapheresis, glucocorticoid pulse therapy, and RTX. There are no previous reports of newly diagnosed TTP with ADAMTS13 inhibitor production after having achieved remission of SLE with RTX. Therefore, our report also discusses the potential mechanisms of production of new autoantibodies after B-cell depletion therapy.<\/jats:p>","DOI":"10.1093\/mrcr\/rxad032","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T12:27:36Z","timestamp":1703852856000},"page":"57-62","source":"Crossref","is-referenced-by-count":0,"title":["Thrombotic thrombocytopenic purpura that developed 3\u2009years after systemic lupus erythematosus had remitted with rituximab therapy"],"prefix":"10.1093","volume":"8","author":[{"given":"Reina","family":"Tsuda","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kido","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuma","family":"Okada","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoi","family":"Kobiyama","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kawataka","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Toyama , Toyama, 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