{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:52:58Z","timestamp":1791402778367,"version":"4.3.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Patients with leprosy are known to tend to develop neuropathic arthropathy, known as Charcot joint. There are no case reports of total knee arthroplasty (TKA) in patients with leprosy with polyarticular neuropathic arthropathy, and the results are unknown. In this study, we report a case of TKA in a patient with leprosy with polyarticular neuropathic arthropathy and discuss its outcomes and indications. Right TKA using the NexGen Legacy Constrained Condylar Knee implant was performed in a 62-year-old man with neuropathic arthropathy in multiple joints with clinical symptoms, particularly in the right knee. Seven years post-operation, the American Knee Society Score-knee and -function, which represent knee function and activities of daily living on a scale of 100 points, were significantly improved compared with preoperative values, from 30 to 99 points and 0 to 60 points, respectively. Indications for arthroplasty for neuropathic arthropathy should be carefully considered in each individual case. In this case, the patient had neuropathic arthropathy in multiple joints; however, TKA was performed because recovery of function in the right knee was expected to significantly improve the patient\u2019s activities of daily living, and a good mid-term clinical outcome was achieved. Therefore, indications for arthroplasty should be considered in patients with systemic neuropathic arthropathy such as leprosy, and with accurate assessment and appropriate implant selection, good long-term outcomes may be expected.<\/jats:p>","DOI":"10.1093\/mrcr\/rxad057","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:55:33Z","timestamp":1697824533000},"page":"219-223","source":"Crossref","is-referenced-by-count":3,"title":["Total knee arthroplasty for\u00a0neuropathic arthropathy in\u00a0a patient with leprosy"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-1162","authenticated-orcid":false,"given":"Sakumo","family":"Kii","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, Saga University , Saga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-8957","authenticated-orcid":false,"given":"Motoki","family":"Sonohata","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Saga Central Hospital , Saga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Mawatari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, Saga University , Saga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"2023122911394565500_R1","article-title":"Leprosy","author":"World Health Organization","year":"2023"},{"key":"2023122911394565500_R2","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1302\/0301-620X.87B10.16596","article-title":"Orthopaedic complications of\u00a0leprosy","volume":"87","author":"Moonot","year":"2005","journal-title":"J Bone Joint Surg Br"},{"key":"2023122911394565500_R3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clindermatol.2014.07.002","article-title":"Clinical aspects of\u00a0leprosy","volume":"33","author":"Talhari","year":"2015","journal-title":"Clin Dermatol"},{"key":"2023122911394565500_R4","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/S0140-6736(07)60457-7","article-title":"The operation of\u00a0the century: total hip replacement","volume":"370","author":"Learmonth","year":"2007","journal-title":"Lancet"},{"key":"2023122911394565500_R5","first-page":"29","article-title":"Two-part total knee arthroplasty: evolution and\u00a0present status","volume":"145","author":"Coventry","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"2023122911394565500_R6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.arth.2004.11.002","article-title":"The early innovators of\u00a0today\u2019s resurfacing condylar knees","volume":"20","author":"Robinson","year":"2005","journal-title":"J Arthroplasty"},{"key":"2023122911394565500_R7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1302\/0301-620X.84B2.0840216","article-title":"Total knee arthroplasty in\u00a0neuropathic arthropathy","volume":"84","author":"Kim","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"2023122911394565500_R8","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1007\/s00167-016-4073-6","article-title":"Total knee arthroplasty in\u00a0patients with Charcot joints","volume":"24","author":"Zeng","year":"2016","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2023122911394565500_R9","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.arth.2018.04.003","article-title":"Primary total knee arthroplasty in\u00a0patients with neuropathic (Charcot) arthropathy: contemporary results","volume":"33","author":"Tibbo","year":"2018","journal-title":"J Arthroplasty"},{"key":"2023122911394565500_R10","first-page":"205","article-title":"Stage classifications, types of\u00a0joint destruction, and\u00a0bone scintigraphy in\u00a0Charcot joint disease","volume":"51","author":"Koshino","year":"1991","journal-title":"Bull Hosp Jt Dis Orthop Inst"},{"key":"2023122911394565500_R11","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/rheumatology\/keq264","article-title":"Arthritis in\u00a0leprosy","volume":"49","author":"Chauhan","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2023122911394565500_R12","first-page":"1380","volume-title":"Arthritis and Allied Conditions","author":"Messner","year":"1979","edition":"9th"},{"key":"2023122911394565500_R13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.00079-13","article-title":"Leprosy in\u00a0the 21st century","volume":"28","author":"White","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"2023122911394565500_R14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/rheumatology\/33.10.963","article-title":"Arthritis of\u00a0leprosy","volume":"33","author":"Gibson","year":"1994","journal-title":"Br J Rheumatol"},{"key":"2023122911394565500_R15","first-page":"181851","article-title":"Charcot-like arthropathy following intra-articular hydrocortisone","volume":"181","author":"Steinberg","year":"1962","journal-title":"JAMA"},{"key":"2023122911394565500_R16","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1007\/s10067-021-05775-8","article-title":"Charcot knee \u2013 presentation, diagnosis, management \u2013 a scoping review","volume":"40","author":"Lu","year":"2021","journal-title":"Clin Rheumatol"},{"key":"2023122911394565500_R17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of\u00a0rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2023122911394565500_R18","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.2337\/dc13-3045","article-title":"Diabetic Charcot neuroarthropathy of\u00a0the knee: conservative treatment options as alternatives to surgery: case reports of\u00a0three patients","volume":"37","author":"Illgner","year":"2014","journal-title":"Diabetes Care"},{"key":"2023122911394565500_R19","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2106\/00004623-197153060-00014","article-title":"Important factors in\u00a0achieving arthrodesis of\u00a0the Charcot knee","volume":"53","author":"Drennan","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"2023122911394565500_R20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2106\/00004623-198062050-00008","article-title":"A study of\u00a0lower-limb mechanics during stair-climbing","volume":"62","author":"Andriacchi","year":"1980","journal-title":"J Bone Joint Surg Am"},{"key":"2023122911394565500_R21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0021-9290(88)90282-5","article-title":"An integrated biomechanical analysis of\u00a0normal stair ascent and\u00a0descent","volume":"21","author":"McFadyen","year":"1988","journal-title":"J Biomech"},{"key":"2023122911394565500_R22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0966-6362(00)00060-6","article-title":"Knee joint kinematics in\u00a0gait and\u00a0other functional activities measured using flexible electrogoniometry: how much knee motion is sufficient for\u00a0normal daily life?","volume":"12","author":"Rowe","year":"2000","journal-title":"Gait Posture"},{"key":"2023122911394565500_R23","doi-asserted-by":"crossref","DOI":"10.1186\/s43019-020-00081-0","article-title":"Results of\u00a0total knee arthroplasty for\u00a0painless, stiff knees","volume":"32","author":"Choi","year":"2020","journal-title":"Knee Surg Relat Res"},{"key":"2023122911394565500_R24","article-title":"Comparison of\u00a0the clinical outcomes following total knee arthroplasty in\u00a0osseous ankylosed and\u00a0non-ankylosed knees using propensity-score matching","author":"Kii","year":"2022","journal-title":"Mod Rheumatol"},{"key":"2023122911394565500_R25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jbiomech.2013.01.007","article-title":"Comparison of\u00a0impact force attenuation by various combinations of\u00a0hip protector and\u00a0flooring material using a simplified fall-impact simulation device","volume":"46","author":"Li","year":"2013","journal-title":"J Biomech"},{"key":"2023122911394565500_R26","article-title":"Study of\u00a0the relation between a bathing custom of\u00a0Japan and\u00a0water saving","volume":"60","author":"Hashida","year":"2013","journal-title":"Proc Annu Conf JSSD"},{"key":"2023122911394565500_R27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00003086-197307000-00023","article-title":"Duo-condylar total knee arthroplasty","volume":"94","author":"Ranawat","year":"1973","journal-title":"Clin Orthop Relat Res"},{"key":"2023122911394565500_R28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.arth.2005.03.022","article-title":"What would you do? Case challenges in\u00a0knee surgery","volume":"20","author":"Vince","year":"2005","journal-title":"J Arthroplasty"},{"key":"2023122911394565500_R29","article-title":"Arthroplasty of\u00a0a Charcot knee","volume":"2","author":"Babazadeh","year":"2010","journal-title":"Orthop Rev (Pavia)"},{"key":"2023122911394565500_R30","first-page":"71","article-title":"Leprosy-induced hip arthritis: a rare case report","volume":"10","author":"Agrawal","year":"2020","journal-title":"J Orthop Case Rep"},{"key":"2023122911394565500_R31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.medmal.2015.09.002","article-title":"Update on\u00a0the epidemiology, diagnosis, and\u00a0treatment of\u00a0leprosy","volume":"45","author":"Reibel","year":"2015","journal-title":"Med Mal Infect"},{"key":"2023122911394565500_R32","doi-asserted-by":"crossref","DOI":"10.1097\/01.PRS.0000133029.07666.D4","article-title":"A rational approach to nasal reconstruction in\u00a0leprosy","volume":"114","author":"Schwarz","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"2023122911394565500_R33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s100960050238","article-title":"Comparative multicenter trial of\u00a0teicoplanin versus cefazolin for\u00a0antimicrobial prophylaxis in\u00a0prosthetic joint implant surgery. Italian Study Group for\u00a0Antimicrobial Prophylaxis in\u00a0Orthopedic Surgery","volume":"18","author":"Periti","year":"1999","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2023122911394565500_R34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00003086-198803000-00018","article-title":"Cefazolin versus cefamandole for\u00a0prophylaxis during total joint arthroplasty","volume":"228","author":"Bryan","year":"1988","journal-title":"Clin Orthop Relat Res"},{"key":"2023122911394565500_R35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"Clinical practice guidelines for\u00a0antimicrobial prophylaxis in\u00a0surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am J Health Syst Pharm"},{"key":"2023122911394565500_R36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00590-019-02598-x","article-title":"Increased constraint of\u00a0rotating hinge knee prosthesis is associated with poorer clinical outcomes as compared to constrained condylar knee prosthesis in\u00a0total knee arthroplasty","volume":"30","author":"Lim","year":"2020","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"2023122911394565500_R37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pain.2013.09.023","article-title":"Similarities between exercise-induced hypoalgesia and\u00a0conditioned pain modulation in\u00a0humans","volume":"155","author":"Vaegter","year":"2014","journal-title":"Pain"},{"key":"2023122911394565500_R38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2010.06.021","article-title":"Dysfunction of\u00a0endogenous pain inhibition during exercise with painful muscles in\u00a0patients with shoulder myalgia and\u00a0fibromyalgia","volume":"151","author":"Lannersten","year":"2010","journal-title":"Pain"},{"key":"2023122911394565500_R39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jpain.2012.09.006","article-title":"A meta-analytic review of\u00a0the hypoalgesic effects of\u00a0exercise","volume":"13","author":"Naugle","year":"2012","journal-title":"J Pain"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxad057\/52357696\/rxad057.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/8\/1\/219\/54920286\/rxad057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/8\/1\/219\/54920286\/rxad057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T12:28:59Z","timestamp":1703852939000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/8\/1\/219\/7325817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10,20]]},"published-print":{"date-parts":[[2023,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxad057","relation":{},"ISSN":["2472-5625"],"issn-type":[{"value":"2472-5625","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,10,20]]}}}