{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:26:35Z","timestamp":1778232395733,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Immunoglobulin G4\u2013related disease (IgG4-RD) is an immune-driven fibroinflammatory disease that presents as tumefactive lesions that not only commonly affects the pancreas, lacrimal and salivary glands, lung, liver and kidney but can also affect any organs. However, involvement of the urinary bladder in IgG4-RD is rarely reported. We describe a case of IgG4-RD involving the urinary bladder mimicking carcinoma and review the published literature\u2014a 39-year-old male presented with complaints of dysuria, urgency and hesitancy. Ultrasound revealed a hyperechoic lesion protruding from the anterior of the urinary bladder wall with partial obstruction to bladder outflow, likely to be a pedunculated bladder mass with high suspicion for malignancy. A contrast-enhanced computed tomography abdomen showed a large irregular lobulated heterogeneously enhancing lesion involving the anteroinferior wall of the urinary bladder extending from mid-body up to the neck region with significant perivesical fat stranding and multiple ill-defined perivesical deposits along with hypodense soft tissue lesion in the perigastric region at the level of the body of the stomach. CT-guided perigastric and ultrasound-guided biopsy from the urinary bladder mass confirmed the diagnosis of IgG4-RD. The patient was treated with glucocorticoids. He is doing well after a 1-year follow-up without recurrence, and a repeat ultrasound showed a significant reduction in the size of the urinary bladder mass. The diagnosis of IgG4-RD should be considered in the differential diagnosis of a urinary bladder mass. High index of suspicion and prompt initiation of therapy are required to minimise residual damage and the need for surgical intervention.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae011","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T19:58:32Z","timestamp":1711569512000},"page":"344-347","source":"Crossref","is-referenced-by-count":4,"title":["Urinary bladder involvement in IgG4-related disease: A case-based review"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8141","authenticated-orcid":false,"given":"Parag","family":"Vijayvergia","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, King George\u2019s Medical University , Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, King George\u2019s Medical University , Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, King George\u2019s Medical University , Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-0714","authenticated-orcid":false,"given":"Urmila","family":"Dhakad","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, King George\u2019s Medical University , Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"2024083002025751400_R1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41584-020-0500-7","article-title":"IgG4-related disease: an update on pathophysiology and implications for clinical care","volume":"16","author":"Perugino","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"2024083002025751400_R2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jaci.2015.12.1330","article-title":"Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease","volume":"138","author":"Mattoo","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2024083002025751400_R3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.imlet.2019.01.008","article-title":"IL-10+ T follicular regulatory cells are associated with the pathogenesis of IgG4-related disease","volume":"207","author":"Ito","year":"2019","journal-title":"Immunol Lett"},{"key":"2024083002025751400_R4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/ard-2023-223950","article-title":"Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured 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