{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:16:54Z","timestamp":1740179814484,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A 53-year-old woman with recurrent stomatitis, genital ulcers, and folliculitis was admitted to Tokyo Medical University Hospital after experiencing visual disturbances for the past 2\u2009weeks and a nonthrobbing headache for the past 3\u2009days. She had also developed numbness in her left extremities. An ophthalmological examination revealed inflammatory changes in the eye. Cerebrospinal fluid analysis showed increased cell counts, protein, and interleukin-6 levels. Brain magnetic resonance imaging revealed multiple high signal intensities on T2-weighted\/fluid-attenuated inversion recovery images of the pons and occipital and parietal lobes. The T2-weighted\/fluid-attenuated inversion recovery high-signal-intensity lesion in the pons was hyperintense on diffusion-weighted imaging and hypointense on apparent diffusion coefficient mapping, suggesting cytotoxic oedema. Another high-signal-intensity lesion on T2-weighted\/fluid-attenuated inversion recovery was isointense to hyperintense on diffusion-weighted imaging and hyperintense on apparent diffusion coefficient, indicating vasogenic oedema. The vasogenic oedema in the left occipital lobe contained a small core that was hyperintense on diffusion-weighted imaging and hypointense on apparent diffusion coefficient, suggesting cytotoxic oedema. The patient was diagnosed with acute neuro-Beh\u00e7et\u2019s disease and responded well to high-dose glucocorticoid and colchicine treatment. The present report emphasises that patients with acute neuro-Beh\u00e7et\u2019s disease may present with cytotoxic oedema in the pons and cerebral spheres. Further reports of similar cases would contribute to a better understanding of the role of cytotoxic oedema in the pathophysiology of neuro-Beh\u00e7et\u2019s disease and help elucidate the mechanisms underlying a unique presentation characterised by a central cytotoxic oedema core within vasogenic oedema.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae032","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T08:21:48Z","timestamp":1718266908000},"page":"188-192","source":"Crossref","is-referenced-by-count":0,"title":["Unique presentation of acute neuro-Beh\u00e7et\u2019s disease involving a cytotoxic oedema core surrounded by vasogenic oedema"],"prefix":"10.1093","volume":"9","author":[{"given":"Shohei","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital , Nishi-Shinjuku 6-7-1, Shinjuku, Tokyo 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