{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:16:54Z","timestamp":1740179814230,"version":"3.37.3"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Polymyositis\/dermatomyositis (DM) is an idiopathic inflammatory myopathy manifesting mainly as symmetrical proximal muscle weakness and\/or typical cutaneous features due to autoimmune mechanisms. Clinically amyopathic dermatomyositis (CADM) is a subset of DM that exhibits only the typical cutaneous features without any clinical muscle symptoms. Several autoantibodies have been found specifically in patients with polymyositis\/DM, including CADM patients. The anti-KS antibody is one of a group of anti-aminoacyl transfer RNA antibodies that are mainly associated with fever, Raynaud\u2019s phenomenon, polyarthritis, and interstitial lung disease (ILD), whereas anti-TIF1-\u03b3 antibody is frequently found in DM patients with malignancy. Here, we report a CADM patient having both anti-KS antibody and anti-TIF1-\u03b3 antibody. This patient developed an acute exacerbation of ILD and was successfully treated with high-dose corticosteroid pulse therapy together with immunosuppressive agents. Although earlier experience had indicated that the seminal characteristic of anti-KS-positive ILD was slowly developing disease onset with little or no progression over the clinical course, the present patient suffered rapidly progressive disease.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae033","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T20:59:52Z","timestamp":1722545992000},"page":"79-83","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of anti-KS and anti-TIF1-\u03b3 antibodies in clinically amyopathic dermatomyositis presenting with rapid progression of interstitial lung disease"],"prefix":"10.1093","volume":"9","author":[{"given":"Yuichiro","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Ohisa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-2088","authenticated-orcid":false,"given":"Yasushi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]},{"name":"Department of Internal Medicine, Keio University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine , 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