{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:16:59Z","timestamp":1740179819386,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Chronic nonbacterial osteomyelitis (CNO) is an uncommon autoinflammatory disorder. Significant effort has recently been spent to better define and treat this disorder including development of consensus treatment protocols, validate disease activity tools, and refining classification criteria. However, the underlying immunopathogenesis of the disease remains elusive. In this report, we describe the simultaneous onset of CNO in siblings. A pathogenic gene mutation was not identified, and these sisters lacked a similar biomarker profile. This report highlights that if a genetic predisposition for CNO exists, it may be related to complex polygenic or multifactorial mechanisms of disease evolution.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae035","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T19:23:24Z","timestamp":1722713004000},"page":"20-26","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous onset of chronic nonbacterial osteomyelitis in siblings"],"prefix":"10.1093","volume":"9","author":[{"given":"Jenny A","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen B","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Department of Radiology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth H","family":"Ristagno","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1037","authenticated-orcid":false,"given":"Matthew L","family":"Basiaga","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatric and Adolescent Medicine, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"2025011615473555600_R1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3389\/fimmu.2022.959575","article-title":"Chronic recurrent multifocal osteomyelitis. 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