{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:24:33Z","timestamp":1790029473084,"version":"4.0.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Patients with rheumatoid arthritis (RA) receiving immunosuppressive therapy including methotrexate (MTX) are at risk of developing lymphoproliferative disorder (LPD). Herein, we report the case of a 61-year-old man who has been treated with MTX and sulfasalazine for seropositive RA since the age of 52\u2009years. He underwent diffusion-weighted whole-body imaging with background signal suppression (DWIBS), which revealed high-intensity lesions in the affected lymph nodes of the cervical, clavicular, and axillary regions. Follow-up DWIBS after MTX withdrawal showed the suppression or disappearance of the high-intensity lesions. This case demonstrates the potential of DWIBS as a new standard imaging modality for MTX-LPD in patients with RA in clinical practice.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae078","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:32:15Z","timestamp":1733470335000},"source":"Crossref","is-referenced-by-count":2,"title":["Imaging using diffusion-weighted whole-body imaging with background signal suppression for methotrexate-associated lymphoproliferative disorder: A case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-8671","authenticated-orcid":false,"given":"Takeshi","family":"Mochizuki","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Rheumatology, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7032-0367","authenticated-orcid":false,"given":"Naoko","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rheumatology, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6655-7281","authenticated-orcid":false,"given":"Mari","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rheumatology, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-350X","authenticated-orcid":false,"given":"Ryo","family":"Hiroshima","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rheumatology, Kamagaya General Hospital , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-2719","authenticated-orcid":false,"given":"Koichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-2005","authenticated-orcid":false,"given":"Katsunori","family":"Ikari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-8406","authenticated-orcid":false,"given":"Ken","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"2025080201014896800_R1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"2025080201014896800_R2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/mr\/roac017","article-title":"Drug treatment algorithm and recommendations from the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis-secondary publication","volume":"33","author":"Kawahito","year":"2023","journal-title":"Mod 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