{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T01:10:21Z","timestamp":1754183421616,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Gout is the most prevalent form of inflammatory arthritis in males as a result of high uric acid levels that cause deposition of monosodium urate crystals in soft tissues, bones, and joints. It commonly presents as a swollen, erythematous, and painful joint. Necrotising fasciitis is rapidly progressing aggressive soft tissue infection that spreads along the fascial planes sparing the skin; it is very uncommon for necrotising fasciitis to occur as a complication of gouty arthritis. We present here a case of a 69-year-old male with a known history of untreated gouty arthritis and tophi over the right foot that complicated into necrtotising fasciits of the leg with extension to the upper thigh, which was surgically debrided but also necessitated above-knee amputation for infection control, survival, and best possible functional outcome of the patient.<\/jats:p>","DOI":"10.1093\/mrcr\/rxae080","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T15:27:23Z","timestamp":1733758043000},"source":"Crossref","is-referenced-by-count":0,"title":["Above-knee amputation in a 69-year-old male with gouty tophi complicated by necrotising fasciitis \u2013 a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-8361","authenticated-orcid":false,"given":"Metasebia Worku","family":"Abebe","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Saint Paul Hospital Millennium Medical College , Addis Ababa,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2814-2623","authenticated-orcid":false,"given":"Abigya Aschalew","family":"Asfaw","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Saint Paul Hospital Millennium Medical College , Addis Ababa,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2025080201012182500_R1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"2025080201012182500_R2","doi-asserted-by":"crossref","first-page":"e790","DOI":"10.3928\/01477447-20110922-34","article-title":"Giant gouty tophi of the hand and wrist","volume":"34","author":"Mittag","year":"2011","journal-title":"Orthopedics"},{"key":"2025080201012182500_R3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7547\/16-110","article-title":"Bilateral first-ray amputation of the foot due to severe tophaceous gout complicated by infection and discharged sinus a case report","volume":"108","author":"Sariyilmaz","year":"2018","journal-title":"J Am Podiatr Med Assoc"},{"key":"2025080201012182500_R4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s004029900061","article-title":"Surgical management of tophaceous gout in the hand","volume":"120","author":"Ertug\u02d8rul \u015eener","year":"2000","journal-title":"Arch Orthop Trauma Surg"},{"article-title":"Necrtotizing Fascitis. (Updated 21 February 2023)","year":"2023","author":"Wallace","key":"2025080201012182500_R5"},{"key":"2025080201012182500_R6","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjab222","article-title":"Retroperitoneal necrotizing fasciitis with the involvement of the anterior abdominal wall following perianal abscess","volume":"2021","author":"Abebe","year":"2021","journal-title":"J Surg Case Rep"},{"key":"2025080201012182500_R7","first-page":"54","article-title":"Amputation in necrotizing fasciitis - dilemma or reality: a case report and literature review","volume":"10","author":"Itsiopoulos","year":"2020","journal-title":"J Orthop Case Rep"},{"key":"2025080201012182500_R8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/rheumatology\/keh097","article-title":"Gout complicated with necrotizing fasciitis \u2013 report of 15 cases","volume":"43","author":"Yu","year":"2004","journal-title":"Rheumatology"},{"key":"2025080201012182500_R9","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000008441","article-title":"Amputation of the first metatarsophalangeal joint due to a giant gouty tophi: a case report","volume":"96","author":"Zhou","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"2025080201012182500_R10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.42347","article-title":"Comparison of rates of lower extremity amputation in patients with and without gout in the US Department of Veterans Affairs Health System","volume":"5","author":"Mikuls","year":"2022","journal-title":"JAMA Network Open"},{"key":"2025080201012182500_R11","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/rheumatology\/keg297","article-title":"Concomitant septic and gouty arthritis \u2013 an analysis of 30 cases","volume":"42","author":"Yu","year":"2003","journal-title":"Rheumatol Oxf Engl"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxae080\/61011855\/rxae080.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/9\/2\/rxae080\/61011855\/rxae080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/9\/2\/rxae080\/61011855\/rxae080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:01:36Z","timestamp":1754110896000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/doi\/10.1093\/mrcr\/rxae080\/7919789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,7,25]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxae080","relation":{},"ISSN":["2472-5625"],"issn-type":[{"type":"electronic","value":"2472-5625"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,10]]},"article-number":"rxae080"}}