{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:21:05Z","timestamp":1770880865437,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Systemic lupus erythematosus (SLE) can present with various symptoms, including rare manifestations such as gangrene. This report describes a 12-year-old girl with SLE who presented with intermittent claudication and gangrene. Although intermittent claudication is rare in paediatric cases, it is essential to consider vascular diseases including those associated with SLE as a potential cause. The patient initially experienced pain, redness, and cold sensations in the right great toe accompanied by intermittent claudication, with symptoms worsening over time. Diagnostic imaging, including contrast-enhanced computed tomography and magnetic resonance imaging, revealed occlusion of the right popliteal artery with associated vasculitis and thrombosis. The diagnosis of SLE and antiphospholipid syndrome was confirmed based on clinical criteria. Treatment included prednisone, methylprednisolone pulse therapy, mycophenolate mofetil, hydroxychloroquine, and anticoagulants. The patient showed significant improvement, with resolution of claudication and effective management of her gangrene through immunosuppressive therapy and careful wound care. This case highlights the importance of considering vascular complications in paediatric SLE and underscores the need for early diagnosis and comprehensive treatment.<\/jats:p>","DOI":"10.1093\/mrcr\/rxaf006","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T15:15:23Z","timestamp":1738422923000},"source":"Crossref","is-referenced-by-count":1,"title":["12-Year-old girl with systemic lupus erythematosus complicated by gangrene and intermittent claudication"],"prefix":"10.1093","volume":"9","author":[{"given":"Takashi","family":"Uechi","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-6030","authenticated-orcid":false,"given":"Tomoko","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Inoki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kitakado","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , 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Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-3137","authenticated-orcid":false,"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2025080201022804100_R1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0022-3476(99)70174-5","article-title":"Diversity in presenting manifestations of systemic lupus erythematosus in children","volume":"135","author":"Iqbal","year":"1999","journal-title":"J Pediatr"},{"key":"2025080201022804100_R2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/jama.1962.03050310006002","article-title":"Gangrene as a manifestation of systemic lupus 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