{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T01:10:21Z","timestamp":1754183421737,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Giant cell arteritis is a systemic vasculitis that causes inflammation in medium- and large-sized blood vessels. The condition can lead to irreversible blindness if not recognised and treated promptly with high-dose steroids. Clinical manifestations typically include headache, jaw pain, fever, and fatigue. However, unusual manifestations of the disease have been reported, including pulmonary nodules, uveitis, pericarditis, and stroke. We report a case of biopsy-confirmed giant cell arteritis in a patient found to have renal cell carcinoma, exhibiting these unusual manifestations simultaneously. This case report demonstrates the atypical presentation that giant cell arteritis may have and the importance of having a high clinical suspicion for the condition.<\/jats:p>","DOI":"10.1093\/mrcr\/rxaf014","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:19:59Z","timestamp":1741911599000},"source":"Crossref","is-referenced-by-count":0,"title":["Unusual systemic conditions in a patient with giant cell arteritis"],"prefix":"10.1093","volume":"9","author":[{"given":"Khalid","family":"El-Jack","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami, FL,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawaz","family":"Naeem","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-3466","authenticated-orcid":false,"given":"Jenelle","family":"Safadi","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Marangoni","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA,","place":["USA"]},{"name":"Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania , Philadelphia, 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