{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:40:04Z","timestamp":1754113204064,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":153,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Myositis-specific autoantibodies found in dermatomyositis (DM) are associated with clinical symptoms and responses to therapy and are useful for diagnosis, treatment selection, and prognostication. Although the prevalence of anti-small ubiquitin-like modifier-activating enzyme (anti-SAE) antibodies in DM patients is low, clinical features such as skin symptoms preceding muscle symptoms and a higher incidence of dysphagia and malignancy have been reported. Herein, we present a case of anti-SAE antibody-positive DM in which panniculitis of the lower legs, a rare dermatological manifestation of DM, preceded muscle symptoms by 2\u00a0months. This case was associated with cervical cancer; however, the clinical course of DM was favourable with glucocorticoid monotherapy. Anti-SAE antibody-positive DM needs to be considered as a differential diagnosis of unexplained panniculitis without muscle symptoms.<\/jats:p>","DOI":"10.1093\/mrcr\/rxaf029","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T07:20:49Z","timestamp":1748848849000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of anti-SAE antibody-positive dermatomyositis presenting with preceding panniculitis as the initial symptom"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9669-6640","authenticated-orcid":false,"given":"Erika","family":"Horimoto","sequence":"first","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-5011","authenticated-orcid":false,"given":"Jun","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-9796","authenticated-orcid":false,"given":"Jun","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3945-4459","authenticated-orcid":false,"given":"Satoshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Internal Medicine, Saiseikai Imabari Hospital , Imabari, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Suemori","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Rheumatic Center, Ozu Memorial Hospital , Ozu, Ehime ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuto","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Toon, Ehime 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cohorts","volume":"7","author":"Ge","year":"2017","journal-title":"Sci Rep"},{"key":"2025080201024802300_ref9","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s10067-019-04562-w","article-title":"Diffuse pruritic erythema as a clinical manifestation in anti-SAE antibody-associated dermatomyositis: a case report and literature review","volume":"38","author":"Jia","year":"2019","journal-title":"Clin Rheumatol"},{"key":"2025080201024802300_ref10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/1346-8138.17000","article-title":"A case of anti-SAE1\/2 antibody-positive dermatomyositis with extensive panniculitis: a possible cutaneous manifestation of treatment resistance","volume":"51","author":"Fujisaki","year":"2024","journal-title":"J Dermatol"},{"key":"2025080201024802300_ref11","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/rheumatology\/kev247","article-title":"High incidence of cancer in anti-small ubiquitin-like modifier activating 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A histopathologic study of 55 cases","volume":"97","author":"Janis","year":"1968","journal-title":"Arch Dermatol"},{"key":"2025080201024802300_ref15","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/jdv.14932","article-title":"Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases","volume":"32","author":"Santos-Briz","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025080201024802300_ref16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.autrev.2008.12.011","article-title":"Clinical entity of lupus erythematosus panniculitis\/lupus erythematosus profundus","volume":"8","author":"Arai","year":"2009","journal-title":"Autoimmun Rev"},{"key":"2025080201024802300_ref17","doi-asserted-by":"crossref","first-page":"290797","DOI":"10.1155\/2014\/290797","article-title":"Anti-MDA5 antibodies in a large Mediterranean population of adults with dermatomyositis","volume":"2014","author":"Labrador-Horrillo","year":"2014","journal-title":"J Immunol Res"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxaf029\/63425582\/rxaf029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/9\/2\/rxaf029\/63425582\/rxaf029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/9\/2\/rxaf029\/63425582\/rxaf029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:02:54Z","timestamp":1754110974000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/doi\/10.1093\/mrcr\/rxaf029\/8155777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,7,25]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxaf029","relation":{},"ISSN":["2472-5625"],"issn-type":[{"type":"electronic","value":"2472-5625"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"rxaf029"}}