{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:14:39Z","timestamp":1787764479438,"version":"build-2784847793"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Eosinophilic granulomatosis with polyangiitis is a systemic vasculitis of small- and medium-sized blood vessels. The disease can manifest itself variably, with the most commonly affected organs including the lungs, sinuses, and peripheral nervous system. Ocular involvement is rare, and the visual prognosis is generally poor. To date, only a few cases have been published describing the ocular manifestations of eosinophilic granulomatosis with polyangiitis. Given the rarity of these complications, diagnosis can be difficult. We report the case of a 60-year-old woman with a history of asthma, sinusitis, and peripheral neuropathy, who presented to our hospital with sudden loss of vision in her right eye. After referral to an ophthalmologist, a diagnosis of central retinal artery occlusion of the right eye was made. Laboratory tests showed hypereosinophilia and mild positivity for antinuclear antibodies. Imaging revealed multiple micronodules in the lung and sinusopathy. Diagnostic tests for stroke, malignancy, and infectious diseases were negative. Based on laboratory, clinical, and imaging data, the patient was diagnosed with eosinophilic granulomatosis with polyangiitis. Treatment with glucocorticoids and cyclophosphamide was started to induce disease remission. The patient achieved a clinical response to treatment with sustained normalisation of peripheral eosinophil counts and maintenance therapy with mepolizumab was initiated. Unfortunately, no improvement in visual function was observed. In patients with sudden vision loss and hypereosinophilia, eosinophilic granulomatosis with polyangiitis should be suspected. Timely diagnosis is essential to initiate appropriate treatment. However, the effect of systemic treatment on improving patients\u2019 visual function is still unclear.<\/jats:p>","DOI":"10.1093\/mrcr\/rxaf056","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:06:18Z","timestamp":1758312378000},"source":"Crossref","is-referenced-by-count":1,"title":["Sudden visual loss and hypereosinophilia: A case of eosinophilic granulomatosis with polyangiitis"],"prefix":"10.1093","volume":"9","author":[{"given":"Angelo","family":"Aita","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Fondazione Policlinico Universitario Campus Bio-Medico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella Tiziana","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Santo Spirito in Sassia Hospital , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Goletti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Santo Spirito in Sassia Hospital , Rome ,","place":["Italy"]},{"name":"Department of Public Health and Infectious Disease, Sapienza University of Rome , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Giovinale","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Santo Spirito in Sassia Hospital , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Velardi","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Santo Spirito in Sassia Hospital , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-6262","authenticated-orcid":false,"given":"Maria Livia","family":"Burzo","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Santo Spirito in Sassia Hospital , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"2025100214213419500_ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/IOP.0000000000001202","article-title":"Ophthalmic eosinophilic granulomatosis with polyangiitis (Churg\u2013Strauss syndrome): a systematic review of the literature","volume":"35","author":"Akella","year":"2019","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025100214213419500_ref2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.autrev.2017.07.007","article-title":"Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg\u2013Strauss): report of 26 patients and review of the 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