{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:17:36Z","timestamp":1781630256241,"version":"3.54.5"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":255,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 59-year-old man developed adult-onset Still\u2019s disease 11\u00a0days after contracting COVID-19. He presented with high fever, polyarthritis, erythema, sore throat, and high levels of C-reactive protein and ferritin; treatment with glucocorticoids and methotrexate led to disease remission. We reviewed the clinical characteristics of 12 cases (11 from the literature and the present case) of adult-onset Still\u2019s disease following COVID-19. Eight cases involved females, with a median age of 54\u00a0years (19\u201359\u00a0years), and the median time from COVID-19 to Still\u2019s disease onset was 12.5\u00a0days. Frequencies of high fever, arthralgia, typical skin lesion, sore throat, liver damage, and increased neutrophil count did not differ from cases of non-COVID-related adult-onset Still\u2019s disease. Serum ferritin levels were increased in all cases (median 6354\u00a0ng\/ml). Complications were infrequent, with macrophage activation syndrome reported in one case. Immunosuppressive drugs and biologic agents were used in five and three cases, respectively, and all cases had good outcomes. Our review suggests that adult-onset Still\u2019s disease develops early after COVID-19, presenting with clinical findings similar to non-COVID-19-related cases, and has few severe complications and a good prognosis.<\/jats:p>","DOI":"10.1093\/mrcr\/rxaf059","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:07:34Z","timestamp":1757678854000},"source":"Crossref","is-referenced-by-count":1,"title":["Adult-onset Still\u2019s disease following COVID-19: a case report and literature review"],"prefix":"10.1093","volume":"9","author":[{"given":"Tsubasa","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]},{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goshi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]},{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]},{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiya","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Soejima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuteru","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuichi","family":"Koarada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-831X","authenticated-orcid":false,"given":"Yoshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, University of Saga , Saga ,","place":["Japan"]},{"name":"Department of Rheumatology, Kouhou-kai Takagi Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"2026011402215411500_ref1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaut.2018.07.018","article-title":"A comprehensive review on adult onset Still\u2019s disease","volume":"93","author":"Giacomelli","year":"2018","journal-title":"J Autoimmun"},{"key":"2026011402215411500_ref2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/14397595.2014.974881","article-title":"Nationwide epidemiological survey of 169 patients with adult Still\u2019s disease in Japan","volume":"25","author":"Asamura","year":"2015","journal-title":"Mod Rheumatol"},{"key":"2026011402215411500_ref3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41584-023-01065-6","article-title":"Recent advances and evolving concepts in Still\u2019s disease","volume":"20","author":"Ruscitti","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"2026011402215411500_ref4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"2026011402215411500_ref5","first-page":"11795441231161640","article-title":"An unforeseen outcome of COVID-19: the triggering of adult-onset Still\u2019s disease","volume":"16","author":"Alzuhaily","year":"2023","journal-title":"Clin Med Insights: Arthritis Musculoskelet Disord"},{"key":"2026011402215411500_ref6","doi-asserted-by":"crossref","first-page":"e7006","DOI":"10.1002\/ccr3.7006","article-title":"Adult-onset Still\u2019s disease after SARS-Cov-2 infection","volume":"11","author":"Achour","year":"2023","journal-title":"Clin Case Rep"},{"key":"2026011402215411500_ref7","doi-asserted-by":"crossref","first-page":"2050313X241233197","DOI":"10.1177\/2050313X241233197","article-title":"Association between adult-onset still\u2019s disease and COVID-19: a report of two cases and brief review","volume":"12","author":"Fet-He","year":"2024","journal-title":"SAGE Open Med Case 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