{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:21:34Z","timestamp":1784035294837,"version":"3.55.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":64,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015629","name":"Jerome L. Greene Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029250","name":"Donald B. and Dorothy L. Stabler Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AR083912 (to CM)"],"award-info":[{"award-number":["1R01AR083912 (to CM)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073208 (to LCR)"],"award-info":[{"award-number":["R01AR073208 (to LCR)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-AR070254 (to AR)"],"award-info":[{"award-number":["P30-AR070254 (to AR)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA237005 (to AV)"],"award-info":[{"award-number":["R01CA237005 (to AV)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with dermatomyositis (DM) and anti-nuclear matrix protein 2 autoantibodies, associations with both cancer and calcinosis are well established. However, the relationship between the progression of calcinosis and the development of cancer remains unknown. Herein, we describe a unique case that prompts hypotheses regarding shared immunologic mechanisms underlying these clinical complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the case of a 46-year-old woman diagnosed with biopsy-proven anti-nuclear matrix protein 2-positive DM manifesting as proximal muscle weakness, myalgias, pruritic rash, and elevations in creatine phosphokinase. Five years into her disease course, the patient developed an abrupt, coincident severe calcinosis and stage IIB squamous cell carcinoma of the cervix. She required aggressive immunosuppression, immunomodulation, and cancer therapy, which ultimately resulted in the remission of her cancer and improvement of her DM, with her calcinosis achieving a quiescent state. Her case describes a parallel course of calcinosis and cancer, and it highlights the challenges of managing refractory DM with malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our case demonstrates that calcinosis and cancer can develop concurrently and follow a parallel course over time, suggesting a possible mechanistic link between the two complications. This report also highlights that communication between rheumatology, medical oncology, and radiation oncology is pivotal for optimally treating these complex patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mrcr\/rxag016","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:46:58Z","timestamp":1772542018000},"source":"Crossref","is-referenced-by-count":1,"title":["Parallel course of calcinosis and cancer in a patient with anti-NXP2-positive dermatomyositis: A case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-8392","authenticated-orcid":false,"given":"Christopher A","family":"Mecoli","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Department of Oncology, Johns Hopkins University School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila N","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Casciola-Rosen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"2026050109561461200_ref1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/acr.23188","article-title":"Antinuclear matrix protein 2 autoantibodies and edema, muscle disease, and malignancy risk in dermatomyositis patients","volume":"69","author":"Albayda","year":"2017","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026050109561461200_ref2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nrrheum.2011.139","article-title":"Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis","volume":"7","author":"Robinson","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"2026050109561461200_ref3","doi-asserted-by":"crossref","first-page":"13030\/qt9n50x88m","DOI":"10.5070\/D3263047981","article-title":"Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature","volume":"26","author":"Cartron","year":"2020","journal-title":"Dermatol Online J"},{"key":"2026050109561461200_ref4","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1002\/art.38093","article-title":"Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1\u03b3","volume":"65","author":"Fiorentino","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2026050109561461200_ref5","first-page":"836246","article-title":"Paraneoplastic dermatomyositis with carcinoma cervix: a rare clinical association","volume":"2014","author":"Kumar","year":"2014","journal-title":"Case Rep Dermatol Med"},{"key":"2026050109561461200_ref6","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","article-title":"2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups","volume":"76","author":"Lundberg","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2026050109561461200_ref7","doi-asserted-by":"crossref","first-page":"e150201","DOI":"10.1172\/JCI150201","article-title":"Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence","volume":"132","author":"Fiorentino","year":"2022","journal-title":"J Clin Invest"},{"key":"2026050109561461200_ref8","doi-asserted-by":"crossref","first-page":"810785","DOI":"10.3389\/fped.2021.810785","article-title":"Is anti-NXP2 autoantibody a risk factor for calcinosis and poor outcome in juvenile dermatomyositis patients? Case series","volume":"9","author":"Toplak","year":"2022","journal-title":"Front Pediatr"},{"key":"2026050109561461200_ref9","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1093\/rheumatology\/keae629","article-title":"Prognostic factors for patients with cancer-associated dermatomyositis: a retrospective, multicentre cohort study of 73 patients","volume":"64","author":"Teboul","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"2026050109561461200_ref10","doi-asserted-by":"crossref","first-page":"217353","DOI":"10.1016\/j.canlet.2024.217353","article-title":"Inhibition of LDHB suppresses the metastatic potential of lung cancer by reducing mitochondrial GSH catabolism","volume":"611","author":"Ge","year":"2024","journal-title":"Cancer Lett"},{"key":"2026050109561461200_ref11","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/ijc.28888","article-title":"Antibodies against high-risk human papillomavirus proteins as markers for invasive cervical cancer","volume":"135","author":"Combes","year":"2014","journal-title":"Int J Cancer"},{"key":"2026050109561461200_ref12","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.7150\/thno.21098","article-title":"Serum immune profiling for early detection of cervical disease","volume":"7","author":"Ewaisha","year":"2017","journal-title":"Theranostics."}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxag016\/67249000\/rxag016.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/1\/rxag016\/67249000\/rxag016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/1\/rxag016\/67249000\/rxag016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:56:18Z","timestamp":1777643778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/doi\/10.1093\/mrcr\/rxag016\/8507953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxag016","relation":{},"ISSN":["2472-5625"],"issn-type":[{"value":"2472-5625","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rxag016"}}