{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:23:23Z","timestamp":1780514603216,"version":"3.54.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Immun4Cure University Hospital Institute \u2018Institute for innovative immunotherapies in autoimmune diseases\u2019","award":["France 2030\/ANR-23-IAHU-009"],"award-info":[{"award-number":["France 2030\/ANR-23-IAHU-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multicentric reticulohistiocytosis is a rare, non-Langerhans cell histiocytosis characterised by papulonodular skin lesions and a rapidly progressive, erosive polyarthritis. We describe the case of a 51-year-old man who presented with a 6 months of acute inflammatory polyarthralgia, synovitis, and extensor tenosynovitis. Concurrently, multiple papulonodular lesions developed on his hands, face, and auricular regions. A skin biopsy demonstrated CD68-positive histiocytes and multinucleated giant cells with eosinophilic \u2018ground-glass\u2019 cytoplasm, confirming multicentric reticulohistiocytosis. Treatment with corticosteroids and methotrexate was ineffective, whereas tumour necrosis factor-alpha inhibitor therapy resulted in meaningful clinical improvement and steroid sparing. Early recognition, imaging, and a biopsy are essential to avoid irreversible joint damage. Although therapeutic evidence is limited to case reports, biologic agents targeting pro-inflammatory cytokines may offer a significant benefit. Awareness of multicentric reticulohistiocytosis is crucial for timely diagnosis and management.<\/jats:p>","DOI":"10.1093\/mrcr\/rxag021","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:50:53Z","timestamp":1772628653000},"source":"Crossref","is-referenced-by-count":1,"title":["A refractory polyarthritis revealing a multicentric reticulohistiocytosis"],"prefix":"10.1093","volume":"10","author":[{"given":"Oc\u00e9ane","family":"Deville-Cavellin","sequence":"first","affiliation":[{"name":"IRMB, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, University of Montpellier, INSERM, Lapeyronie University Hospital, CHU Montpellier , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Nallet","sequence":"additional","affiliation":[{"name":"IRMB, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, University of Montpellier, INSERM, Lapeyronie University Hospital, CHU Montpellier , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ralandison","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CH Mende , Mende ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Trinquet","sequence":"additional","affiliation":[{"name":"Pathology Department, Montpellier University Hospital , Montpellier ,","place":["France"]},{"name":"Institute of Functional Genomics, Montpellier University, CNRS, INSERM , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-3773","authenticated-orcid":false,"given":"Yves-Marie","family":"Pers","sequence":"additional","affiliation":[{"name":"IRMB, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, University of Montpellier, INSERM, Lapeyronie University Hospital, CHU Montpellier , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"2026040802021799700_ref1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.clindermatol.2006.07.010","article-title":"Multicentric reticulohistiocytosis","volume":"24","author":"Tajirian","year":"2006","journal-title":"Clin Dermatol"},{"key":"2026040802021799700_ref2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.berh.2016.07.002","article-title":"Multicentric reticulohistiocytosis: rheumatology perspective","volume":"30","author":"Toz","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2026040802021799700_ref3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13023-022-02311-y","article-title":"Clinical characteristics of multicentric reticulohistiocytosis and distinguished features from rheumatoid arthritis: a single-center experience in China","volume":"17","author":"Zou","year":"2022","journal-title":"Orphanet J Rare Dis"},{"key":"2026040802021799700_ref4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jbspin.2015.02.003","article-title":"Assessment and effective targeting of interleukin-1 in multicentric reticulohistyocytosis","volume":"82","author":"Aouba","year":"2015","journal-title":"Joint Bone Spine"},{"key":"2026040802021799700_ref5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.medcli.2024.06.015","article-title":"Multicentric reticulohistiocytosis with good response to tocilizumab","volume":"163","author":"Serrano Serra","year":"2024","journal-title":"Med Clin (Barc)"},{"key":"2026040802021799700_ref6","first-page":"565","article-title":"Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient","volume":"32","author":"Shannon","year":"2005","journal-title":"J Rheumatol"}],"container-title":["Modern 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