{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:49:32Z","timestamp":1791568172048,"version":"4.3.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parvovirus B19 infection can closely mimic flares of autoimmune diseases such as rheumatoid arthritis, posing diagnostic challenges. We report a case of a 50-year-old man with seropositive rheumatoid arthritis who presented with acute symmetrical polyarthropathy, a transient rash, and profound anaemia. Initially managed as a rheumatoid flare, further evaluation revealed severe normocytic anaemia with reticulocytopenia. Bone marrow aspiration demonstrated pure red cell aplasia with characteristic giant proerythroblasts containing intranuclear inclusions. Parvovirus B19 DNA was detected by polymerase chain reaction. The patient was treated with intravenous immunoglobulin, resulting in rapid hematologic recovery and resolution of symptoms. This case underscores the importance of considering parvovirus B19 as a differential diagnosis in immunocompromised or chronically ill patients presenting with atypical rheumatologic or hematologic features. Early recognition and appropriate therapy are essential to avoid misdiagnosis and ensure optimal patient outcomes.<\/jats:p>","DOI":"10.1093\/mrcr\/rxag031","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:43:37Z","timestamp":1778327017000},"source":"Crossref","is-referenced-by-count":1,"title":["Rheumatoid arthritis flare mimicry by parvovirus B19"],"prefix":"10.1093","volume":"10","author":[{"given":"Pradnya","family":"Patil","sequence":"first","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences (AIIMS) , Guwahati ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-1471","authenticated-orcid":false,"given":"Gwenette Andrea","family":"War","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences (AIIMS) , Guwahati ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashis Priyadarshan","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Hematology Christian Medical College (CMC) , Vellore ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshwar","family":"Raipalle","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences (AIIMS) , Guwahati ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupen","family":"Barman","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences (AIIMS) , Guwahati ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026053011363239200_ref1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4103\/jfmpc.jfmpc_25_19","article-title":"Acute parvovirus B19 infection presenting as rheumatoid arthritis mimic","volume":"8","author":"Alexander","year":"2019","journal-title":"J Fam Med Prim Care"},{"key":"2026053011363239200_ref2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1128\/CMR.15.3.485-505.2002","article-title":"Human parvovirus B19","volume":"15","author":"Heegaard","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"2026053011363239200_ref3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000493390","article-title":"Rheumatoid arthritis: a brief overview of the treatment","volume":"27","author":"Bullock","year":"2018","journal-title":"Med Princ Pract"},{"key":"2026053011363239200_ref4","doi-asserted-by":"publisher","first-page":"113960","DOI":"10.1016\/j.intimp.2024.113960","article-title":"Clinical implications of human Parvovirus B19 infection on autoimmunity and autoimmune diseases","volume":"147","author":"Tzang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"2026053011363239200_ref5","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1182\/blood-2016-05-717140","article-title":"Pure red cell aplasia","volume":"128","author":"Means","year":"2016","journal-title":"Blood"},{"key":"2026053011363239200_ref6","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1186\/s13256-021-03141-5","article-title":"Pure red cell aplasia secondary to rheumatoid arthritis: a case report","volume":"15","author":"Weerasinghe","year":"2021","journal-title":"J Med Case Rep"},{"key":"2026053011363239200_ref7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.idcr.2016.05.005","article-title":"Atypical rashes in adult human parvovirus B19 infection; atypical is typical","volume":"5","author":"Hirai","year":"2016","journal-title":"IDCases"},{"key":"2026053011363239200_ref8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0046-8177(00)80215-4","article-title":"Unusual bone marrow manifestations of parvovirus B19 infection in immunocompromised patients","volume":"31","author":"Crook","year":"2000","journal-title":"Hum Pathol"},{"key":"2026053011363239200_ref9","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1537-2995.2010.02591.x","article-title":"Parvovirus B19 infection transmitted by transfusion of red blood cells confirmed by molecular analysis of linked donor and recipient samples","volume":"50","author":"Yu","year":"2010","journal-title":"Transfusion"},{"key":"2026053011363239200_ref10","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1093\/cid\/cis1046","article-title":"Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus B19 infection: a retrospective study of 10 patients and review of the literature","volume":"56","author":"Crabol","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2026053011363239200_ref11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1537-2995.2007.01503.x","article-title":"Neutralization of human parvovirus B19 by plasma and intravenous immunoglobulins","volume":"48","author":"Modrof","year":"2008","journal-title":"Transfusion"},{"key":"2026053011363239200_ref12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10156-008-0636-X","article-title":"Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection","volume":"14","author":"Ogawa","year":"2008","journal-title":"J Infect Chemother Off J Jpn Soc Chemother"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxag031\/68267844\/rxag031.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/1\/rxag031\/68267844\/rxag031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/1\/rxag031\/68267844\/rxag031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:36:38Z","timestamp":1780155398000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/doi\/10.1093\/mrcr\/rxag031\/8675868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxag031","relation":{},"ISSN":["2472-5625"],"issn-type":[{"value":"2472-5625","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rxag031"}}