{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:06:41Z","timestamp":1788977201710,"version":"build-2803163510"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Background: Beh\u00e7et\u2019s disease (BD) is a multisystem inflammatory disorder with variable manifestations. Although hepatic involvement is rare, abnormal liver enzymes may occasionally be observed. We describe two patients with BD who developed autoimmune hepatitis, confirmed by liver biopsy. Case presentation: We report two Iranian patients \u2212 one male and one female \u2212 diagnosed with BD, who later developed persistently elevated liver enzymes. Both had elevated IgG levels, negative viral hepatitis markers, and liver biopsy findings compatible with autoimmune hepatitis. Due to limited retrospective serologic data, the diagnosis was established based on a multidisciplinary clinicopathological assessment and response to immunosuppressive therapy. Sonography showed fatty liver in both cases. Treatment with azathioprine and prednisolone led to the normalization of liver enzymes over a long-term follow-up. Conclusions: Although it is uncommon, AIH can co-occur with BD and should be considered in patients with persistently elevated transaminases. A liver biopsy is crucial for a definitive diagnosis. Early immunosuppressive therapy can prevent disease progression.<\/jats:p>","DOI":"10.1093\/mrcr\/rxag062","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:40:37Z","timestamp":1787658037000},"source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune hepatitis in two patients with Beh\u00e7et\u2019s disease"],"prefix":"10.1093","volume":"10","author":[{"given":"Majid","family":"Alikhani","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Science , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathology, School of Medicine, Shariati Hospital, Tehran University of Medical Science , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Nikvarz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Students Scientific Research Center, Tehran University of Medical Science , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3123-1149","authenticated-orcid":false,"given":"Somayeh","family":"Soroureddin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Emam Ali Hospital, Alborz University of Medical Science , Alborz ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026090913171158800_ref1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00002281-200401000-00008","article-title":"Beh\u00e7et syndrome","volume":"16","author":"Yurdakul","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"2026090913171158800_ref2","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"51","author":"Manns","year":"2010","journal-title":"Hepatology."},{"key":"2026090913171158800_ref3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"Hennes","year":"2008","journal-title":"Hepatology."},{"key":"2026090913171158800_ref4","first-page":"221","article-title":"Chronic active hepatitis and Beh\u00e7et's disease: a case report","volume":"17","author":"Manna","year":"1985","journal-title":"Ital J Gastroenterol"},{"key":"2026090913171158800_ref5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/kel329","article-title":"Autoimmunity vs autoinflammation in Beh\u00e7et's disease: do we oversimplify a complex disorder?","volume":"45","author":"Direskeneli","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"2026090913171158800_ref6","first-page":"475","article-title":"Liver involvement in Beh\u00e7et's disease","volume":"28","author":"Song","year":"2009","journal-title":"Clin Rheumatol"},{"key":"2026090913171158800_ref7","first-page":"230","article-title":"Autoimmune hepatitis in a patient with Beh\u00e7et's disease: a case report and review of the literature","volume":"3","author":"Tanida","year":"2010","journal-title":"Clin J Gastroenterol"},{"key":"2026090913171158800_ref8","first-page":"246","article-title":"Autoimmune diseases co-existing with autoimmune hepatitis: an analysis of 120 cases","volume":"4","author":"Ramos-Casals","year":"2005","journal-title":"Autoimmun Rev"}],"container-title":["Modern Rheumatology Case 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