{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:05:33Z","timestamp":1790255133898,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pregnancy after anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis-associated interstitial lung disease is rarely described, and preconception management remains uncertain. A 29-year-old woman presented with fever, arthralgia, cough, characteristic Gottron\u2019s and inverse Gottron\u2019s papules, normal muscle enzyme levels, mild interstitial lung abnormalities on high-resolution computed tomography, and positivity for anti-melanoma differentiation-associated gene 5 antibody. Due to the potential risk of rapid pulmonary deterioration, she received prednisolone, a calcineurin inhibitor, and intravenous cyclophosphamide, followed by maintenance immunosuppression. Mycophenolate mofetil was discontinued as part of preconception planning 24\u00a0months after disease onset. After two biochemical pregnancies that ended before ultrasonographic confirmation of a gestational sac, a subsequent pregnancy was confirmed at ~36\u00a0months after disease onset while she was receiving prednisolone 10\u00a0mg\/day and tacrolimus. The pregnancy was not complicated by relapse of dermatomyositis or interstitial lung disease, a hypertensive disorder, gestational diabetes, foetal growth restriction, or non-reassuring foetal status. She delivered a healthy female infant at 38\u00a0weeks and 3\u00a0days of gestation by vaginal delivery. At &amp;gt;4\u00a0years postpartum, she remained relapse-free, and the antibody remained negative. This case suggests that a planned pregnancy may be feasible in carefully selected patients after sustained preconception disease control, the discontinuation of teratogenic drugs, and the continuation of pregnancy-compatible immunosuppression under multidisciplinary surveillance; serial anti-melanoma differentiation-associated gene 5 antibody measurements may provide adjunctive information when interpreted alongside clinical, pulmonary function, and imaging assessments.<\/jats:p>","DOI":"10.1093\/mrcr\/rxag085","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:22:02Z","timestamp":1787937722000},"source":"Crossref","is-referenced-by-count":0,"title":["Planned pregnancy after remission of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis-associated interstitial lung disease: More than 4\u00a0years of postpartum follow-up"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-8678","authenticated-orcid":false,"given":"Daisuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences , Niigata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Takamura","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences , Niigata ,","place":["Japan"]},{"name":"Department of Rheumatology, Niigata Rheumatic Center , Shibata Hospital, Shibata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Sakai","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences , Niigata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Clinical Rheumatology, Niigata Rinko Hospital , Niigata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences , Niigata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences , Niigata 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