{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:15:39Z","timestamp":1792800939517,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Drug-induced lupus erythematosus is an autoimmune condition that resembles systemic lupus erythematosus and occurs after exposure to specific medications, including tumour necrosis factor alpha inhibitors. We report a rare case of golimumab-induced lupus erythematosus complicated by macrophage activation syndrome, angioedema, and severe dysphagia with anti-galactocerebroside antibodies detected. A 57-year-old woman with ulcerative colitis developed facial swelling, malar rash, arthritis, pancytopenia, hyperferritinaemia, hypocomplementaemia, and proteinuria after long-term treatment with tumour necrosis factor alpha inhibitors, most recently golimumab. Bone marrow examination demonstrated haemophagocytosis, confirming macrophage activation syndrome. Computed tomography and endoscopy revealed soft tissue and oesophageal oedema consistent with angioedema. Despite improvement of systemic inflammation following high-dose glucocorticoids and intravenous cyclophosphamide, severe dysphagia persisted. A videofluoroscopic swallowing study demonstrated pharyngeal muscle dysfunction, and serum testing detected anti-galactocerebroside immunoglobulin G antibodies. Neurological imaging and electrophysiological studies were unremarkable. Swallowing function gradually recovered after discontinuation of golimumab. This case highlights that golimumab-induced lupus erythematosus may trigger multiple autoimmune complications, including macrophage activation syndrome, angioedema, and antibody-associated neuromuscular dysphagia. Awareness of these potentially life-threatening manifestations is essential for early recognition and appropriate management in patients receiving tumour necrosis factor alpha inhibitors.<\/jats:p>","DOI":"10.1093\/mrcr\/rxag096","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:28:19Z","timestamp":1791113299000},"source":"Crossref","is-referenced-by-count":1,"title":["Golimumab-induced lupus erythematosus complicated by angioedema and anti\u2013galactocerebroside antibody-positive dysphagia"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-657X","authenticated-orcid":false,"given":"Makoto","family":"Misaki","sequence":"first","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-7041","authenticated-orcid":false,"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reo","family":"Yamazato","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Fujio","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026102111524922000_ref1","first-page":"746","article-title":"New concepts in the pathogenesis of drug-induced lupus","volume":"73","author":"Yung","year":"1995","journal-title":"Lab Investig"},{"key":"2026102111524922000_ref2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autrev.2010.07.005","article-title":"Drug-induced lupus: an update","volume":"10","author":"Katz","year":"2010","journal-title":"Autoimmun Rev"},{"key":"2026102111524922000_ref3","doi-asserted-by":"publisher","first-page":"rkz023.004","DOI":"10.1093\/rap\/rkz023.004","article-title":"Drug-induced lupus as a trigger for macrophage activation syndrome","volume":"3","author":"Leith","year":"2019","journal-title":"Rheumatol Adv Pract"},{"key":"2026102111524922000_ref4","doi-asserted-by":"crossref","first-page":"R545","DOI":"10.1186\/ar1715","article-title":"Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey","volume":"7","author":"De Bandt","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"2026102111524922000_ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/1756283X16676194","article-title":"Golimumab pharmacokinetics in ulcerative colitis: a literature review","volume":"10","author":"Harzallah","year":"2017","journal-title":"Ther Adv Gastroenterol"},{"key":"2026102111524922000_ref6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0025-6196(11)60668-X","article-title":"Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic","volume":"84","author":"Wetter","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"2026102111524922000_ref7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/MD.0b013e3181441a68","article-title":"Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases","volume":"86","author":"Ramos-Casals","year":"2007","journal-title":"Medicine (Baltimore)"},{"key":"2026102111524922000_ref8","first-page":"559","article-title":"Adalimumab-induced lupus erythematosus in Crohn\u2019s disease patients previously treated with infliximab","volume":"57","author":"Ma\u00f1osa","year":"2008","journal-title":"Gut."},{"key":"2026102111524922000_ref9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1874312901206010315","article-title":"Anti-tumor necrosis factor-\u03b1 induced systemic lupus erythematosus","volume":"6","author":"Almoallim","year":"2012","journal-title":"Open Rheumatol J"},{"key":"2026102111524922000_ref10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.47102\/annals-acadmedsg.V36N2p142","article-title":"Angioedema and systemic lupus erythematosus--a complementary association?","volume":"36","author":"Lahiri","year":"2007","journal-title":"Ann Acad Med Singap"},{"key":"2026102111524922000_ref11","first-page":"e46874","article-title":"Esophageal dysmotility disorder and dysphagia as initial manifestations of lupus","volume":"15","author":"Hegazy","year":"2023","journal-title":"Cureus."},{"key":"2026102111524922000_ref12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/1876894600901010010","article-title":"The gastrointestinal manifestations of systemic lupus erythematosus: a survey of the literature","volume":"1","author":"Schulz","year":"2009","journal-title":"Open Autoimmun J"},{"key":"2026102111524922000_ref13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2013.11.016","article-title":"Clinical features in Guillain-Barr\u00e9 syndrome with anti-gal-C antibody","volume":"337","author":"Samukawa","year":"2014","journal-title":"J Neurol Sci"},{"key":"2026102111524922000_ref14","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1272\/jnms.JNMS.2024_91-402","article-title":"Unilateral vocal cord paralysis in a patient with anti-galactocerebroside antibodies: a case report","volume":"91","author":"Yanagihashi","year":"2024","journal-title":"J Nippon Med Sch"},{"key":"2026102111524922000_ref15","first-page":"001387","article-title":"An overlapping case of miller fisher syndrome and the pharyngeal-cervical-brachial variant of Guillain-Barr\u00e9 syndrome","volume":"7","author":"Martins","year":"2020","journal-title":"Eur J Case Rep Intern Med"}],"container-title":["Modern Rheumatology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mrcr\/advance-article-pdf\/doi\/10.1093\/mrcr\/rxag096\/71603301\/rxag096.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/2\/rxag096\/71603301\/rxag096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mrcr\/article-pdf\/10\/2\/rxag096\/71603301\/rxag096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:52:53Z","timestamp":1792597973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mrcr\/article\/doi\/10.1093\/mrcr\/rxag096\/8864918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6,29]]}},"URL":"https:\/\/doi.org\/10.1093\/mrcr\/rxag096","relation":{},"ISSN":["2472-5625"],"issn-type":[{"value":"2472-5625","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rxag096"}}