{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:54:18Z","timestamp":1790085258462,"version":"4.0.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selenomethionine (SeMet) is a widely used food supplement. However, the research on the effect of SeMet on intestinal immune function is not enough. Therefore, in this experiment, SeMet was added to the diet of chickens, and lipopolysaccharide (LPS) was used as harmful stimulation to study the effect of SeMet on intestinal immune function in chickens. We chose chicken jejunum as the research object. The results showed that LPS treatment decreased the expressions of selenoproteins and induced inflammatory reaction, cytokine disorder, decreases of immunoglobulin levels, heat shock protein expression disorder, and decreases of defensin expression levels in jejunum. However, dietary SeMet can effectively alleviate the above injury caused by LPS. Our results showed that SeMet could improve the intestinal immunity in chickens, and feeding SeMet could alleviate the intestinal immune dysfunction caused by LPS. The application range of SeMet in feed can be roughly given through our experiment; i.e. 0.35\u20130.5\u00a0mg\/kg SeMet was effective. We speculated that dietary SeMet could effectively alleviate the intestinal immune dysfunction caused by harmful stimulation and help to resist the further damage caused by harmful stimulation.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab003","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T12:12:18Z","timestamp":1612008738000},"source":"Crossref","is-referenced-by-count":18,"title":["Selenomethionine ameliorates LPS-induced intestinal immune dysfunction in chicken jejunum"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-9759","authenticated-orcid":false,"given":"Yuan","family":"Cui","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-0215","authenticated-orcid":false,"given":"Hongjin","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China"},{"name":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"2021120812595195500_bib1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"2021120812595195500_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archinte.167.2.148","article-title":"Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial","volume":"167","author":"Hurwitz","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"2021120812595195500_bib3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2009.03.026","article-title":"Selenoprotein P: expression, functions, and roles in mammals","volume":"1790","author":"Burk","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2021120812595195500_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtn.2019.08.003","article-title":"lnc-3215 suppression leads to calcium overload in selenium deficiency-induced chicken heart lesion via the lnc-3215-miR-1594-TNN2 pathway","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"2021120812595195500_bib5","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.285.5432.1393","article-title":"Dual function of the selenoprotein PHGPx during sperm maturation","volume":"285","author":"Ursini","year":"1999","journal-title":"Science"},{"key":"2021120812595195500_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"2021120812595195500_bib7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-154-10-201105170-00005","article-title":"Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial","volume":"154","author":"Rayman","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"2021120812595195500_bib8","first-page":"563","article-title":"Human health and selenium","volume":"54","author":"Patel","year":"2000","journal-title":"Indian J. Med. Sci."},{"key":"2021120812595195500_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/mnfr.200700465","article-title":"On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health","volume":"52","author":"Schomburg","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"2021120812595195500_bib10","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jc.2006-1821","article-title":"The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies","volume":"92","author":"Negro","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021120812595195500_bib11","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/pcp\/pcr070","article-title":"Characterization of the selenite uptake mechanism in the coccolithophore Emiliania huxleyi (Haptophyta)","volume":"52","author":"Araie","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"2021120812595195500_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1043-4526(03)47002-2","article-title":"The nutritional significance, metabolism and toxicology of selenomethionine","volume":"47","author":"Schrauzer","year":"2003","journal-title":"Adv. Food Nutr. Res."},{"key":"2021120812595195500_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijrobp.2013.06.2063","article-title":"Selenoprotein P inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury","volume":"87","author":"Eckers","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"2021120812595195500_bib14","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/jf062010a","article-title":"Effect of selenium source and level in hen's diet on tissue selenium deposition and egg selenium concentrations","volume":"55","author":"Pan","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"2021120812595195500_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.livsci.2015.05.004","article-title":"Effects of organic, inorganic, and nano-Se on growth performance, antioxidant capacity, cellular and humoral immune responses in broiler chickens exposed to oxidative stress","volume":"178","author":"Boostani","year":"2015","journal-title":"Livest. Sci."},{"key":"2021120812595195500_bib16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/10408398.2014.934437","article-title":"In vivo and in vitro testing for selenium and selenium compounds bioavailability assessment in foodstuff","volume":"57","author":"Moreda-Pineiro","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2021120812595195500_bib17","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1016\/j.foodchem.2013.06.027","article-title":"Chemical characterisation and speciation of organic selenium in cultivated selenium-enriched Agaricus bisporus","volume":"141","author":"Maseko","year":"2013","journal-title":"Food Chem."},{"key":"2021120812595195500_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"2021120812595195500_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.23.011702.073036","article-title":"Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function","volume":"23","author":"Ziegler","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"2021120812595195500_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/08941930390153069","article-title":"Disruption of the small-intestine mucosal barrier after intestinal occlusion: a study with light and electron microscopy","volume":"16","author":"Kabaroudis","year":"2003","journal-title":"J. Invest. Surg."},{"issue":"6","key":"2021120812595195500_bib21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/1751-2980.12879","article-title":"The role of cytokine and immune responses in intestinal fibrosis","volume":"21","author":"Yang","year":"2020","journal-title":"J. Dig. Dis."},{"key":"2021120812595195500_bib22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.clnu.2013.03.020","article-title":"Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches","volume":"32","author":"Massironi","year":"2013","journal-title":"Clin. Nutr."},{"key":"2021120812595195500_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cyto.2012.05.027","article-title":"Transcriptional regulation of IL-17A and other inflammatory markers during the development of soybean meal-induced enteropathy in the distal intestine of Atlantic salmon (Salmo salar L.)","volume":"60","author":"Marjara","year":"2012","journal-title":"Cytokine"},{"key":"2021120812595195500_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2013.12.016","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis","volume":"66","author":"Oliveira","year":"2014","journal-title":"Cytokine"},{"key":"2021120812595195500_bib25","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2016.09.023","article-title":"Update on the use of immunoglobulin in human disease: a review of evidence","volume":"139","author":"Perez","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"2021120812595195500_bib26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jviromet.2012.07.002","article-title":"Evaluation of anti-norovirus IgY from egg yolk of chickens immunized with norovirus P particles","volume":"186","author":"Dai","year":"2012","journal-title":"J. Virol. Methods"},{"key":"2021120812595195500_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vetimm.2009.12.011","article-title":"IgY: a promising antibody for use in immunodiagnostic and in immunotherapy","volume":"135","author":"da Silva","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"2021120812595195500_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0361-9230(00)00325-7","article-title":"Roles of molecular chaperones in the nervous system","volume":"53","author":"Ohtsuka","year":"2000","journal-title":"Brain Res. Bull."},{"key":"2021120812595195500_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0014-5793(97)01311-2","article-title":"Developmental regulation of the plant mitochondrial matrix located HSP70 chaperone and its role in protein import","volume":"417","author":"Dudley","year":"1997","journal-title":"FEBS Lett."},{"key":"2021120812595195500_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0959-440X(97)80006-1","article-title":"Chaperone-assisted protein folding","volume":"7","author":"Martin","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2021120812595195500_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molcel.2010.10.006","article-title":"The heat shock response: life on the verge of death","volume":"40","author":"Richter","year":"2010","journal-title":"Mol. Cell"},{"key":"2021120812595195500_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/0929866526666190925152957","article-title":"Clinical applications of antimicrobial peptides (AMPs): where do we stand now?","volume":"27","author":"Divyashree","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"2021120812595195500_bib33","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.it.2014.07.004","article-title":"Host defense peptides: front-line immunomodulators","volume":"35","author":"Mansour","year":"2014","journal-title":"Trends Immunol."},{"key":"2021120812595195500_bib34","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"2021120812595195500_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.1365-2052.1998.00338.x","article-title":"Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow","volume":"29","author":"Brockus","year":"1998","journal-title":"Anim. Genet."},{"key":"2021120812595195500_bib36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.imlet.2007.03.007","article-title":"Avian beta-defensin nomenclature: a community proposed update","volume":"110","author":"Lynn","year":"2007","journal-title":"Immunol. Lett."},{"key":"2021120812595195500_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2164-5-56","article-title":"A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins","volume":"5","author":"Xiao","year":"2004","journal-title":"BMC Genomics"},{"key":"2021120812595195500_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11356-019-06753-z","article-title":"Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt\/\u03b2-catenin pathway","volume":"27","author":"Zhang","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"2021120812595195500_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fsi.2020.03.047","article-title":"Glyphosate induces lymphocyte cell dysfunction and apoptosis via regulation of miR-203 targeting of PIK3R1 in common carp (Cyprinus carpio L.)","volume":"101","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"2021120812595195500_bib40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.fsi.2020.05.009","article-title":"Bisphenol A regulates cytochrome P450 1B1 through miR-27b-3p and induces carp lymphocyte oxidative stress leading to apoptosis","volume":"102","author":"Liu","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"2021120812595195500_bib41","doi-asserted-by":"crossref","first-page":"124682","DOI":"10.1016\/j.jhazmat.2020.124682","article-title":"Regulation of H2S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p\/TGFBR3 axis and the involvement of oxidative stress in this process","volume":"406","author":"Qianru","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"2021120812595195500_bib42","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12011-015-0604-0","article-title":"Expression of selenoprotein genes is affected by heat stress in IPEC-J2 cells","volume":"172","author":"Cao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"2021120812595195500_bib43","doi-asserted-by":"crossref","first-page":"1170.3","DOI":"10.1096\/fasebj.30.1_supplement.1170.3","article-title":"Impact of 15\u00a0kDa selenoprotein and dietary selenium on initiation and promotion in colorectal carcinogenesis","volume":"30","author":"Tsuji","year":"2016","journal-title":"FASEB J."},{"key":"2021120812595195500_bib44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2010.05.035","article-title":"Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction","volume":"49","author":"Speckmann","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"2021120812595195500_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1039\/C9MT00216B","article-title":"Selenomethionine alleviates LPS-induced chicken myocardial inflammation by regulating the miR-128-3p-p38 MAPK axis and oxidative stress","volume":"12","author":"Liu","year":"2020","journal-title":"Metallomics"},{"key":"2021120812595195500_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/fcp.12528","article-title":"Dexmedetomidine attenuates LPS-mediated BV2 microglia cells inflammation via inhibition of glycolysis","volume":"34","author":"Meng","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"2021120812595195500_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s12011-015-0536-8","article-title":"Selenium deficiency influences the mRNA expression of selenoproteins and cytokines in chicken erythrocytes","volume":"171","author":"Luan","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"2021120812595195500_bib48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/1753425912456223","article-title":"Effect of l-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge","volume":"19","author":"Zhu","year":"2013","journal-title":"Innate Immun"},{"key":"2021120812595195500_bib49","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/vr.160.7.232","article-title":"Vitamin E deficiency and decreased serum immunoglobulin concentrations in a population of donkeys","volume":"160","author":"Verdonck","year":"2007","journal-title":"Vet. Rec."},{"key":"2021120812595195500_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/1745039X.2015.1034828","article-title":"Transient changes of enzyme activities and expression of stress proteins in the small intestine of piglets after weaning","volume":"69","author":"Tao","year":"2015","journal-title":"Arch. Anim. Nutr."},{"key":"2021120812595195500_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1439-0396.2010.01075.x","article-title":"Fasting and refeeding modulate the expression of stress proteins along the gastrointestinal tract of weaned pigs","volume":"95","author":"Lalles","year":"2011","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"2021120812595195500_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3382\/ps\/pez570","article-title":"Proper cold stimulation starting at an earlier age can enhance immunity and improve adaptability to cold stress in broilers","volume":"99","author":"Su","year":"2020","journal-title":"Poult. Sci."},{"key":"2021120812595195500_bib53","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3382\/ps.2011-01948","article-title":"Differential gene expression profiles of beta-defensins in the crop, intestine, and spleen using a necrotic enteritis model in 2 commercial broiler chicken lines","volume":"91","author":"Hong","year":"2012","journal-title":"Poult. Sci."},{"key":"2021120812595195500_bib54","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1017\/S0007114511000420","article-title":"The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects","volume":"106","author":"Hu","year":"2011","journal-title":"Br. J. Nutr."},{"key":"2021120812595195500_bib55","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12011-015-0584-0","article-title":"Dietary selenium increases the antioxidant levels and ATPase activity in the arteries and veins of poultry","volume":"172","author":"Cao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"2021120812595195500_bib56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12917-018-1508-y","article-title":"Selenium ameliorates Staphylococcus aureus-induced inflammation in bovine mammary epithelial cells by inhibiting activation of TLR2, NF-\u03baB and MAPK signaling pathways","volume":"14","author":"Wang","year":"2018","journal-title":"BMC Vet. Res."},{"key":"2021120812595195500_bib57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ijbiomac.2017.03.008","article-title":"Immunomodulatory effect of low molecular-weight seleno-aminopolysaccharides in intestinal epithelial cells","volume":"99","author":"Gu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"2021120812595195500_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.vetpar.2014.10.025","article-title":"Immune and anti-oxidant effects of in ovo selenium proteinate on post-hatch experimental avian necrotic enteritis","volume":"206","author":"Lee","year":"2014","journal-title":"Vet. Parasitol."},{"key":"2021120812595195500_bib59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12917-018-1578-x","article-title":"Effects of vitamin E, inorganic selenium, bacterial organic selenium, and their combinations on immunity response in broiler chickens","volume":"14","author":"Dalia","year":"2018","journal-title":"BMC Vet. Res."},{"key":"2021120812595195500_bib60","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.3168\/jds.2007-0348","article-title":"Selenium addition to colostrum increases immunoglobulin G absorption by newborn calves","volume":"90","author":"Kamada","year":"2007","journal-title":"J. Dairy Sci."},{"key":"2021120812595195500_bib61","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12011-015-0527-9","article-title":"Effect of selenium deficiency on nitric oxide and heat shock proteins in chicken erythrocytes","volume":"171","author":"Zhao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"2021120812595195500_bib62","first-page":"460","article-title":"Effects of selenium-enriched probiotics on heart lesions by influencing the mRNA expressions of selenoproteins and heat shock proteins in heat stressed broiler chickens","volume":"36","author":"Khan","year":"2016","journal-title":"Pak. Vet. J."},{"key":"2021120812595195500_bib63","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12011-019-01789-1","article-title":"Selenomethionine relieves inflammation in the chicken trachea caused by LPS though inhibiting the NF-\u03baB pathway","volume":"194","author":"Shi","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"2021120812595195500_bib64","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/00071668.2014.984160","article-title":"Dietary sodium selenite affects host intestinal and systemic immune response and disease susceptibility to necrotic enteritis in commercial broilers","volume":"56","author":"Xu","year":"2015","journal-title":"Br. Poult. Sci."}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/metallomics\/advance-article-pdf\/doi\/10.1093\/mtomcs\/mfab003\/36184053\/mfab003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/13\/3\/mfab003\/41653721\/mfab003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/13\/3\/mfab003\/41653721\/mfab003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T07:48:21Z","timestamp":1724399301000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/doi\/10.1093\/mtomcs\/mfab003\/6127319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,8]]}},"URL":"https:\/\/doi.org\/10.1093\/mtomcs\/mfab003","relation":{},"ISSN":["1756-591X"],"issn-type":[{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2021,2,3]]},"article-number":"mfab003"}}