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Here, we recorded and compared proteomic and transcriptomic changes in hippocampus of male BALB\/c mice exposed to two doses of MeHg. Mice were fed diets spiked with 0.28\u00a0mg MeHg kg\u20131, 5\u00a0mg MeHg kg\u20131, or an unspiked control diet for 77 days. Total mercury content was significantly (P\u00a0&amp;lt;\u00a00.05) increased in brain tissue of both MeHg-exposed groups (18 \u00b1 2\u00a0mg Hg kg\u20131 and 0.56\u00a0\u00b1 0.06\u00a0mg Hg kg\u20131). Hippocampal protein and ribonucleic acid (RNA) expression levels were significantly altered both in tissues from mice receiving a low dose MeHg (20 proteins\/294 RNA transcripts) and a high dose MeHg (61 proteins\/876 RNA transcripts). The majority but not all the differentially expressed features in hippocampus were dose dependent. The combined use of transcriptomic and proteomic profiling data provided insight on the influence of MeHg on neurotoxicity, energy metabolism, and oxidative stress through several regulated features and pathways, including RXR function and superoxide radical degradation.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab022","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:32:14Z","timestamp":1619098334000},"source":"Crossref","is-referenced-by-count":12,"title":["RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB\/c mice"],"prefix":"10.1093","volume":"13","author":[{"given":"Ragnhild Marie","family":"Mellingen","sequence":"first","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"},{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Secher","family":"Myrmel","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Kristoffer","family":"Lie","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef Daniel","family":"Rasinger","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Madsen","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"},{"name":"Department of Biology, University of Copenhagen, K\u00f8benhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Jakob","family":"N\u00f8stbakken","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"issue":"1","key":"2021120812593713700_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.autrev.2016.09.020","article-title":"Mercury as an environmental stimulus in the development of autoimmunity: a systematic review","volume":"16","author":"Crowe","year":"2017","journal-title":"Autoimmun. 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