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First, spatially resolved imaging analysis was deployed to investigate gold translocation from the lungs to the spleen and to investigate the distribution pattern of gold in the spleen parenchyma itself. Using the same instrumental setup, laser ablation-inductively coupled plasma-mass spectrometry in single particle mode was applied to determine the species of translocated gold. Single particle analysis allows the determination of particle size distributions and therefore to distinguish between ionic species, intact nanoparticles, and agglomerates. A translocation of instilled gold from the lungs to the spleen was demonstrated for gold nanoparticles of 30 and 50\u00a0nm diameter. Furthermore single particle analysis revealed the translocation of intact gold nanoparticles in a non-agglomerated state.<\/jats:p>","DOI":"10.1093\/mtomcs\/mfab028","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T19:09:12Z","timestamp":1620500952000},"source":"Crossref","is-referenced-by-count":13,"title":["Spatially and size-resolved analysis of gold nanoparticles in rat spleen after intratracheal instillation by laser ablation-inductively coupled plasma-mass spectrometry"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-131X","authenticated-orcid":false,"given":"Ilona D","family":"Nordhorn","sequence":"first","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rthe","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-7519","authenticated-orcid":false,"given":"Christine","family":"Verlemann","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Vennemann","sequence":"additional","affiliation":[{"name":"IBE R&D Institute for Lung Health gGmbH , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-3887","authenticated-orcid":false,"given":"Robin","family":"Schmid","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-377X","authenticated-orcid":false,"given":"Matthias","family":"Elinkmann","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-2487","authenticated-orcid":false,"given":"Michael","family":"Sperling","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"},{"name":"European Virtual Institute for Speciation Analysis , 64000 Pau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-8601","authenticated-orcid":false,"given":"Martin","family":"Wiemann","sequence":"additional","affiliation":[{"name":"IBE R&D Institute for Lung Health gGmbH , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-6787","authenticated-orcid":false,"given":"Uwe","family":"Karst","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"2","key":"2024052508152131700_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jaci.2016.02.023","article-title":"A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects","volume":"138","author":"Li","year":"2016","journal-title":"J. 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